| Literature DB >> 9406545 |
M Eberstadt, B Huang, E T Olejniczak, S W Fesik.
Abstract
NMR studies of the lymphoproliferation mutant (V238N) of the Fas death domain indicate that helix 3 is unfolded. This local structural change abolishes binding to FADD--a protein that interacts with Fas and also contains a death domain--and causes the accumulation of autoreactive T cells.Entities:
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Year: 1997 PMID： 9406545 DOI： 10.1038/nsb1297-983
Source DB: PubMed Journal: Nat Struct Biol ISSN： 1072-8368