Literature DB >> 9406415

A mutant of Listeria monocytogenes LO28 unable to induce an acid tolerance response displays diminished virulence in a murine model.

L Marron1, N Emerson, C G Gahan, C Hill.   

Abstract

Exposing Listeria monocytogenes LO28 to sublethal pH induces protection against normally lethal pH conditions, a phenomenon known as the acid tolerance response. We identified a mutant, L. monocytogenes ATR1, which is incapable of inducing such tolerance, either against low pH or against any other stress tested. The virulence of this mutant was considerably decreased, suggesting that the acid tolerance response contributes to in vivo survival of L. monocytogenes.

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Year:  1997        PMID： 9406415      PMCID： PMC168821          DOI： 10.1128/aem.63.12.4945-4947.1997

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  6 in total

1.  Identification of a ClpC ATPase required for stress tolerance and in vivo survival of Listeria monocytogenes.

Authors:  C Rouquette; M T Ripio; E Pellegrini; J M Bolla; R I Tascon; J A Vázquez-Boland; P Berche
Journal:  Mol Microbiol       Date:  1996-09       Impact factor: 3.501

2.  Acid tolerance in Listeria monocytogenes: the adaptive acid tolerance response (ATR) and growth-phase-dependent acid resistance.

Authors:  M J Davis; P J Coote; C P O'Byrne
Journal:  Microbiology       Date:  1996-10       Impact factor: 2.777

3.  Construction and properties of Tn917-lac, a transposon derivative that mediates transcriptional gene fusions in Bacillus subtilis.

Authors:  J B Perkins; P J Youngman
Journal:  Proc Natl Acad Sci U S A       Date:  1986-01       Impact factor: 11.205

4.  Insertional mutagenesis of Listeria monocytogenes with a novel Tn917 derivative that allows direct cloning of DNA flanking transposon insertions.

Authors:  A Camilli; A Portnoy; P Youngman
Journal:  J Bacteriol       Date:  1990-07       Impact factor: 3.490

5.  Acid adaptation of Listeria monocytogenes can enhance survival in acidic foods and during milk fermentation.

Authors:  C G Gahan; B O'Driscoll; C Hill
Journal:  Appl Environ Microbiol       Date:  1996-09       Impact factor: 4.792

6.  Adaptive acid tolerance response in Listeria monocytogenes: isolation of an acid-tolerant mutant which demonstrates increased virulence.

Authors:  B O'Driscoll; C G Gahan; C Hill
Journal:  Appl Environ Microbiol       Date:  1996-05       Impact factor: 4.792
  6 in total
  16 in total

1.  Identification and disruption of lisRK, a genetic locus encoding a two-component signal transduction system involved in stress tolerance and virulence in Listeria monocytogenes.

Authors:  P D Cotter; N Emerson; C G Gahan; C Hill
Journal:  J Bacteriol       Date:  1999-11       Impact factor: 3.490

Review 2.  Surviving the acid test: responses of gram-positive bacteria to low pH.

Authors:  Paul D Cotter; Colin Hill
Journal:  Microbiol Mol Biol Rev       Date:  2003-09       Impact factor: 11.056

Review 3.  How the bacterial pathogen Listeria monocytogenes mediates the switch from environmental Dr. Jekyll to pathogenic Mr. Hyde.

Authors:  Michael J Gray; Nancy E Freitag; Kathryn J Boor
Journal:  Infect Immun       Date:  2006-05       Impact factor: 3.441

4.  Virulent rough filaments of Listeria monocytogenes from clinical and food samples secreting wild-type levels of cell-free p60 protein.

Authors:  N J Rowan; A A Candlish; A Bubert; J G Anderson; K Kramer; J McLauchlin
Journal:  J Clin Microbiol       Date:  2000-07       Impact factor: 5.948

5.  Role for HtrA in stress induction and virulence potential in Listeria monocytogenes.

Authors:  Helena M Stack; Roy D Sleator; Megan Bowers; Colin Hill; Cormac G M Gahan
Journal:  Appl Environ Microbiol       Date:  2005-08       Impact factor: 4.792

6.  Isolation of rifampin-resistant mutants of Listeria monocytogenes and their characterization by rpoB gene sequencing, temperature sensitivity for growth, and interaction with an epithelial cell line.

Authors:  R Morse; K O'Hanlon; M Virji; M D Collins
Journal:  J Clin Microbiol       Date:  1999-09       Impact factor: 5.948

7.  Listeria monocytogenes PerR mutants display a small-colony phenotype, increased sensitivity to hydrogen peroxide, and significantly reduced murine virulence.

Authors:  Rosemarie Rea; Colin Hill; Cormac G M Gahan
Journal:  Appl Environ Microbiol       Date:  2005-12       Impact factor: 4.792

8.  Identification of the gene encoding the alternative sigma factor sigmaB from Listeria monocytogenes and its role in osmotolerance.

Authors:  L A Becker; M S Cetin; R W Hutkins; A K Benson
Journal:  J Bacteriol       Date:  1998-09       Impact factor: 3.490

9.  Role of Listeria monocytogenes sigma(B) in survival of lethal acidic conditions and in the acquired acid tolerance response.

Authors:  Adriana Ferreira; David Sue; Conor P O'Byrne; Kathryn J Boor
Journal:  Appl Environ Microbiol       Date:  2003-05       Impact factor: 4.792

10.  CO2- and anaerobiosis-induced changes in physiology and gene expression of different Listeria monocytogenes strains.

Authors:  Anne-Marie Jydegaard-Axelsen; Poul Erik Høiby; Kim Holmstrøm; Nicholas Russell; Susanne Knøchel
Journal:  Appl Environ Microbiol       Date:  2004-07       Impact factor: 4.792
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