Ferrihemoglobin formation by monohydroxy aniline derivatives in erythrocytes of some avian species in comparison with mammals.

Ferrihemoglobin formation nitrosobenzene and p-, m- and o-animophenol was studied in erythrocyte supspensions from a number of avian and mammalian species. Compared with the mammalian erythrocytes, bird red cells show little species differences in susceptibility. In birds, dose-effect relationship are different for nitrosobenzene and the aminophenols: using low concentration nitrosobenzene is more active than the aminophenols, while at higher concentrations o-aminophenol is at least equally effective. In birds, o-aminophenol is about eight times more potent than p-aminophenol. m-Anminophenol is not an inducer of ferrihemoglobin in erythrocytes of the cat, the goat and the Japanese quail.