| Literature DB >> 9405387 |
C Capon1, J M Wieruszeski, J Lemoine, J C Byrd, H Leffler, Y S Kim.
Abstract
This article describes oligosaccharide structures of mucin isolated from nude mouse xenograft tumors produced by LS174T-HM7 cells, a subline of the human colon carcinoma LS174T with higher metastatic tendency and higher mucin production. A striking feature of the oligosaccharides of the LS174T-HM7 xenograft tumor mucin was a predominance of sulfated Lewis X determinants: HSO3-Galbeta1-4(Fucalpha1-3)GlcNAc. In addition to one previously known saccharide with one sulfated Lewis X determinant, the HM7 xenograft tumor mucin contained multiple novel structures containing one, two, or three sulfated Lewis X determinants. This determinant, known to act as a selectin ligand, has been found previously in minor saccharide components of human milk as well as mucins, but never before as a predominant structure in one mucin source.Entities:
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Year: 1997 PMID： 9405387 DOI： 10.1074/jbc.272.51.31957
Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157