Literature DB >> 9404947

Neurotrophin-3 mRNA expression in rat intrafusal muscle fibres after denervation and reinnervation.

J C Copray1, N Brouwer.   

Abstract

We have studied the regulation of the expression of neurotrophin-3 (NT-3) mRNA in neonatal and adult rat muscle spindles after denervation and after denervation followed by reinnervation. Denervation of the intrafusal fibres did not result in an upregulation of the NT-3 mRNA expression but decreased this expression below the detection limit of the in situ hybridization method. Reinnervation of intrafusal fibres restored the NT-3 mRNA expression. The results suggest that the expression of NT-3 mRNA in postnatal muscle spindles is controlled by neuronal factors. The intrafusal fibre derived NT-3 may act as an instructive, feedback messenger for innervating neurons and may play a role in stabilizing and maintaining functional neuromuscular connections.

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Year:  1997        PMID： 9404947     DOI： 10.1016/s0304-3940(97)00747-7

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  6 in total

1.  Permanent central synaptic disconnection of proprioceptors after nerve injury and regeneration. II. Loss of functional connectivity with motoneurons.

Authors:  Katie L Bullinger; Paul Nardelli; Martin J Pinter; Francisco J Alvarez; Timothy C Cope
Journal:  J Neurophysiol       Date:  2011-08-10       Impact factor: 2.714

2.  Permanent central synaptic disconnection of proprioceptors after nerve injury and regeneration. I. Loss of VGLUT1/IA synapses on motoneurons.

Authors:  Francisco J Alvarez; Haley E Titus-Mitchell; Katie L Bullinger; Michal Kraszpulski; Paul Nardelli; Timothy C Cope
Journal:  J Neurophysiol       Date:  2011-08-10       Impact factor: 2.714

3.  Treatment with Riluzole Restores Normal Control of Soleus and Extensor Digitorum Longus Muscles during Locomotion in Adult Rats after Sciatic Nerve Crush at Birth.

Authors:  Wojciech Zmysłowski; Anna M Cabaj; Urszula Sławińska
Journal:  PLoS One       Date:  2017-01-17       Impact factor: 3.240

4.  Muscle spindle reinnervation using transplanted embryonic dorsal root ganglion cells after peripheral nerve transection in rats.

Authors:  Kenichi Asano; Tomonori Nakano; Katsuhiro Tokutake; Hisao Ishii; Takanobu Nishizuka; Katsuyuki Iwatsuki; Tetsuro Onishi; Shigeru Kurimoto; Michiro Yamamoto; Masahiro Tatebe; Hitoshi Hirata
Journal:  Cell Prolif       Date:  2019-07-02       Impact factor: 6.831

Review 5.  Signals Orchestrating Peripheral Nerve Repair.

Authors:  Michela Rigoni; Samuele Negro
Journal:  Cells       Date:  2020-07-24       Impact factor: 6.600

6.  Sensory protection of rat muscle spindles following peripheral nerve injury and reinnervation.

Authors:  Amal Elsohemy; Richard Butler; James R Bain; Margaret Fahnestock
Journal:  Plast Reconstr Surg       Date:  2009-12       Impact factor: 5.169
  6 in total

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