Literature DB >> 9404565

IgE responses to Dermatophagoides pteronyssinus native major allergens Der p 1 and Der p 2 during long-term specific immunotherapy.

F Mastrandrea1, G Serio, A Minardi, G Coradduzza, N Rossi, G Scarcia, G Maietta, A Iacobelli, C Lamanna, A Tursi.   

Abstract

We investigated by ELISA the IgE response to whole extract of the house-dust mite Dermatophagoides pteronyssinus (Dp) and to the native major allergens, Der p 1 and Der p 2, in sera from 18 adult patients (group A) with Dp-allergic asthma before (t0) and 1, 2, 3, and 4 (t1-t4) years after subcutaneous specific immunotherapy (SIT). A qualitative reduction (P = 0.05) of the IgE responses to Dp and Der p 2 was observed from t1 to t4, but a highly statistical significant decrease appeared at t3 (P < 0.01). With regard to Der p 1 IgE values, the immunotherapy induced a significant decrease (P < 0.01) at t3, but not before. In group A, the IgE responses to Der p 1 and Der p 2 were not correlated at t0 (rs = 0.31; P = 0.21) but were correlated at t3 (rs = 0.78; P = 0.001). We also examined sera from 14 adult patients (group B, same SIT schedule as group A) who were without respiratory symptoms at the end of the third year (t3) of Dp SIT. At this time (t3), there were no significant differences in Der p 1 and Der p 2 IgE levels between group A and group B.

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Year:  1997        PMID: 9404565     DOI: 10.1111/j.1398-9995.1997.tb00185.x

Source DB:  PubMed          Journal:  Allergy        ISSN: 0105-4538            Impact factor:   13.146


  3 in total

1.  Construction of a Der p2-transgenic plant for the alleviation of airway inflammation.

Authors:  C C Lee; H Ho; K T Lee; S T Jeng; B L Chiang
Journal:  Cell Mol Immunol       Date:  2011-05-23       Impact factor: 11.530

Review 2.  Chinese Guideline on allergen immunotherapy for allergic rhinitis.

Authors:  Yixiao Bao; Jianjun Chen; Lei Cheng; Yinshi Guo; Suling Hong; Weijia Kong; He Lai; Houyong Li; Huabin Li; Jing Li; Tianying Li; Xiaoping Lin; Shixi Liu; Zheng Liu; Hongfei Lou; Juan Meng; Qianhui Qiu; Kunling Shen; Wei Tang; Zezhang Tao; Chengshuo Wang; Xiangdong Wang; Qingyu Wei; Li Xiang; Hua Xie; Yu Xu; Gehua Zhang; Yuan Zhang; Yiwu Zheng; Yuxiang Zhi; Dehua Chen; Haiyu Hong; Quansheng Li; Lin Liu; Yifan Meng; Nan Wang; Yihui Wang; Yue Zhou; Luo Zhang
Journal:  J Thorac Dis       Date:  2017-11       Impact factor: 2.895

3.  Serum and salivary IgE, IgA, and IgG4 antibodies to Dermatophagoides pteronyssinus and its major allergens, Der p1 and Der p2, in allergic and nonallergic children.

Authors:  Diego O Miranda; Deise A O Silva; Jorge F C Fernandes; Meimei G J Queirós; Hamilton F Chiba; Leandro H Ynoue; Rafael O Resende; Janethe D O Pena; Sun-Sang J Sung; Gesmar R S Segundo; Ernesto A Taketomi
Journal:  Clin Dev Immunol       Date:  2011-10-05
  3 in total

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