Literature DB >> 9402974

Asynchronous replication of p53 and 21q22 loci in chronic lymphocytic leukemia.

A Amiel1, T Litmanovich, E Gaber, M Lishner, L Avivi, M D Fejgin.   

Abstract

In this study, in order to evaluate the replication pattern and the cell cycle dynamics of normal and malignant cells from patients with chronic lymphocytic leukemia, we applied the FISH technique with the p53 gene. Asynchrony was determined by the presence of one single and one set of double dots in the same cell. The rate of asynchronous replication was significantly higher in malignant cells than in normal cells (a mean of 28 vs 13, respectively, P = 0.023). There were proportionately more cells with two single dots among the normal cells (P = 0.0047). These results probably reflect the changes in gene replication and cell cycle progression that occur in malignant cells.

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Year:  1997        PMID： 9402974     DOI： 10.1007/s004390050619

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  10 in total

1.  Replication asynchrony increases in women at risk for aneuploid offspring.

Authors:  A Amiel; O Reish; E Gaber; I Kedar; R Diukman; M Fejgin
Journal:  Chromosome Res       Date:  2000       Impact factor: 5.239

2.  High concentrations of long interspersed nuclear element sequence distinguish monoallelically expressed genes.

Authors:  Elena Allen; Steve Horvath; Frances Tong; Peter Kraft; Elizabeth Spiteri; Arthur D Riggs; York Marahrens
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-08       Impact factor: 11.205

3.  Alterations in replication timing of cancer-related genes in malignant human breast cancer cells.

Authors:  Andrew Fritz; Seema Sinha; Narasimharao Marella; Ronald Berezney
Journal:  J Cell Biochem       Date:  2013-05       Impact factor: 4.429

4.  Replication status as a possible marker for genomic instability in cells originating from genotypes with balanced rearrangements.

Authors:  A Amiel; E Levi; O Reish; R Sharony; M D Fejgin
Journal:  Chromosome Res       Date:  2001       Impact factor: 5.239

5.  Coincidence of synteny breakpoints with malignancy-related deletions on human chromosome 3.

Authors:  Maria Kost-Alimova; Hajnalka Kiss; Ludmila Fedorova; Ying Yang; Jan P Dumanski; George Klein; Stefan Imreh
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-08       Impact factor: 11.205

Review 6.  Review: cell cycle aberrations and neurodegeneration.

Authors:  D J Bonda; V P Bajić; B Spremo-Potparevic; G Casadesus; X Zhu; M A Smith; H-G Lee
Journal:  Neuropathol Appl Neurobiol       Date:  2010-01-06       Impact factor: 8.090

7.  Replication profile of PCDH11X and PCDH11Y, a gene pair located in the non-pseudoautosomal homologous region Xq21.3/Yp11.2.

Authors:  N D Wilson; L J N Ross; J Close; R Mott; T J Crow; E V Volpi
Journal:  Chromosome Res       Date:  2007-05-29       Impact factor: 5.239

8.  The X-chromosome instability phenotype in Alzheimer's disease: a clinical sign of accelerating aging?

Authors:  Vladan P Bajić; Biljana Spremo-Potparević; Lada Zivković; David J Bonda; Sandra L Siedlak; Gemma Casadesus; Hyoung-Gon Lee; Mark A Smith
Journal:  Med Hypotheses       Date:  2009-07-31       Impact factor: 1.538

9.  Is the time dimension of the cell cycle re-entry in AD regulated by centromere cohesion dynamics?

Authors:  Vladan P Bajić; Biljana Spremo-Potparević; Lada Zivković; Ninoslav Djelić; Mark A Smith
Journal:  Biosci Hypotheses       Date:  2008

10.  Asynchronous DNA Replication of Biallelically Expressed Genes in Human Peripheral Blood Lymphocytes as a Prognostic Sign of Cancer.

Authors:  V V Tsepenko; T G Shkavrova; V N Cherkesov; E V Golub; G F Mikhailova
Journal:  Sovrem Tekhnologii Med       Date:  2021-06-28
  10 in total

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