P S Bernstein1, K B Digre, D J Creel. 1. Moran Eye Center, University of Utah School of Medicine, Salt Lake City 84132, USA. paul.bernstein@hsc.utah.edu
Abstract
PURPOSE: To report a case of retinopathy associated with chronic occupational exposure to ethyl-m-aminobenzoic acid methanesulfonate (MS-222), a retinotoxic fish anesthetic. METHOD: Case report with electroretinograms to document changes in visual electrophysiology. RESULTS: An ichthyologist with a long history of skin exposure to MS-222 was initially examined for decreased vision, photophobia, and photopsia. His electroretinogram abnormalities were similar to those seen in animal models of acute MS-222 toxicity. After terminating MS-222 contact for 7 months, his vision returned to normal, and his electroretinogram improved. CONCLUSION: Individuals with occupational exposure to MS-222 should exercise caution to avoid systemic absorption of this retinotoxic compound.
PURPOSE: To report a case of retinopathy associated with chronic occupational exposure to ethyl-m-aminobenzoic acid methanesulfonate (MS-222), a retinotoxic fish anesthetic. METHOD: Case report with electroretinograms to document changes in visual electrophysiology. RESULTS: An ichthyologist with a long history of skin exposure to MS-222 was initially examined for decreased vision, photophobia, and photopsia. His electroretinogram abnormalities were similar to those seen in animal models of acute MS-222toxicity. After terminating MS-222 contact for 7 months, his vision returned to normal, and his electroretinogram improved. CONCLUSION: Individuals with occupational exposure to MS-222 should exercise caution to avoid systemic absorption of this retinotoxic compound.
Authors: Ilana A Galex; Cameron M Gallant; Nicole D'Avignon; Lauren M Kuchenbrod; Craig A Fletcher; Allison R Rogala Journal: J Am Assoc Lab Anim Sci Date: 2020-03-12 Impact factor: 1.232
Authors: Erin M Katz; David K Chu; Kerriann M Casey; Katechan Jampachaisri; Stephen A Felt; Cholawat Pacharinsak Journal: J Am Assoc Lab Anim Sci Date: 2020-06-12 Impact factor: 1.232