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Literature DB >> 9402381

Quinolone arthropathy in animals versus children.

J E Burkhardt¹, J N Walterspiel, U B Schaad.

Abstract

The use of quinolones in children and accumulation of data on the pharmacodynamics of these drugs have been limited and delayed by concern regarding their chondrotoxicity. A comprehensive review of the findings in animals compared with the cumulative published findings in children and adolescents (>7,000 to date) allows the conclusion that such concern is not justified. Prospective controlled studies in children are justifiable in view of a continuing lack of correlation between findings in juvenile animals and those in children and because of the selected therapeutic advantages of the current and newer quinolones.

Entities: Chemical Disease Species

Mesh：

Substances：
Quinolones

Year: 1997 PMID： 9402381 DOI： 10.1086/516119

Source DB: PubMed Journal: Clin Infect Dis ISSN： 1058-4838 Impact factor: 9.079

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Cited

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Quinolone arthropathy in animals versus children.

1. Gatifloxacin Therapy in Otitis Media in Children.

2. Provider and health care system response to a bioterrorist attack.

3. In vivo efficacies and pharmacokinetics of DX-619, a novel des-fluoro(6) quinolone, against Streptococcus pneumoniae in a mouse lung infection model.

4. High prevalence of antimicrobial resistance among Shigella isolates in the United States tested by the National Antimicrobial Resistance Monitoring System from 1999 to 2002.

5. The place of quinolones in paediatric anti-infective therapy.

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7. Pharmacokinetics of gatifloxacin in infants and children.

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9. The effect of fluoroquinolone antibiotics on growing cartilage in the lamb model.

10. Colonic diverticular abscess presenting as chronic diarrhea: a case report.