Literature DB >> 9402184

T1rho-relaxation in articular cartilage: effects of enzymatic degradation.

U Duvvuri1, R Reddy, S D Patel, J H Kaufman, J B Kneeland, J S Leigh.   

Abstract

Spin-lattice relaxation in the rotating frame (T1rho) dispersion spectroscopy and imaging were used to study normal and enzymatically degraded bovine articular cartilage. Normal specimens demonstrate significant T1rho "dispersion" (approximately 60 to approximately 130 ms) in the 100 Hz to 9 kHz frequency range. Proteoglycan-degraded specimens have 33% greater T1rho values than collagen-degraded or normal samples. T1rho-weighted images reveal structure not found in conventional T1- or T2-weighted images. Our results suggest that T1rho measurements are selectively sensitive to proteoglycan content. The potential of this method in distinguishing the early degenerative changes in cartilage associated with osteoarthritis is discussed.

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Year:  1997        PMID： 9402184     DOI： 10.1002/mrm.1910380602

Source DB:  PubMed          Journal:  Magn Reson Med        ISSN： 0740-3194            Impact factor:   4.668


  111 in total

1.  Ultrashort echo time MR imaging of osteochondral junction of the knee at 3 T: identification of anatomic structures contributing to signal intensity.

Authors:  Won C Bae; Jerry R Dwek; Richard Znamirowski; Sheronda M Statum; Juan C Hermida; Darryl D D'Lima; Robert L Sah; Jiang Du; Christine B Chung
Journal:  Radiology       Date:  2010-03       Impact factor: 11.105

2.  Biexponential T1ρ relaxation mapping of human knee cartilage in vivo at 3 T.

Authors:  Azadeh Sharafi; Ding Xia; Gregory Chang; Ravinder R Regatte
Journal:  NMR Biomed       Date:  2017-06-20       Impact factor: 4.044

3.  Evaluation of bone bruises and associated cartilage in anterior cruciate ligament-injured and -reconstructed knees using quantitative t(1ρ) magnetic resonance imaging: 1-year cohort study.

Authors:  Alexander A Theologis; Daniel Kuo; Jonathan Cheng; Radu I Bolbos; Julio Carballido-Gamio; C Benjamin Ma; Xiaojuan Li
Journal:  Arthroscopy       Date:  2010-10-29       Impact factor: 4.772

4.  Water magnetic relaxation dispersion in biological systems: the contribution of proton exchange and implications for the noninvasive detection of cartilage degradation.

Authors:  U Duvvuri; A D Goldberg; J K Kranz; L Hoang; R Reddy; F W Wehrli; A J Wand; S W Englander; J S Leigh
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-16       Impact factor: 11.205

Review 5.  Sodium and T1rho MRI for molecular and diagnostic imaging of articular cartilage.

Authors:  Arijitt Borthakur; Eric Mellon; Sampreet Niyogi; Walter Witschey; J Bruce Kneeland; Ravinder Reddy
Journal:  NMR Biomed       Date:  2006-11       Impact factor: 4.044

6.  Regional variation in T1ρ and T2 times in osteoarthritic human menisci: correlation with mechanical properties and matrix composition.

Authors:  M Son; S B Goodman; W Chen; B A Hargreaves; G E Gold; M E Levenston
Journal:  Osteoarthritis Cartilage       Date:  2013-03-14       Impact factor: 6.576

7.  Quantitative assessment of bone marrow edema-like lesion and overlying cartilage in knees with osteoarthritis and anterior cruciate ligament tear using MR imaging and spectroscopic imaging at 3 Tesla.

Authors:  Xiaojuan Li; Benjamin C Ma; Radu I Bolbos; Robert Stahl; Jesus Lozano; Jin Zuo; Katrina Lin; Thomas M Link; Marc Safran; Sharmila Majumdar
Journal:  J Magn Reson Imaging       Date:  2008-08       Impact factor: 4.813

Review 8.  T₁ρ MRI of human musculoskeletal system.

Authors:  Ligong Wang; Ravinder R Regatte
Journal:  J Magn Reson Imaging       Date:  2014-06-17       Impact factor: 4.813

9.  Composite metric R2  - R1ρ (1/T2  - 1/T1ρ ) as a potential MR imaging biomarker associated with changes in pain after ACL reconstruction: A six-month follow-up.

Authors:  Colin Russell; Valentina Pedoia; Sharmila Majumdar
Journal:  J Orthop Res       Date:  2016-09-16       Impact factor: 3.494

10.  Relationship between trabecular bone structure and articular cartilage morphology and relaxation times in early OA of the knee joint using parallel MRI at 3 T.

Authors:  R I Bolbos; Jin Zuo; Suchandrima Banerjee; Thomas M Link; C Benjamin Ma; Xiaojuan Li; Sharmila Majumdar
Journal:  Osteoarthritis Cartilage       Date:  2008-04-02       Impact factor: 6.576
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