| Literature DB >> 9402149 |
K E Kinnamon1, B T Poon, W L Hanson, V B Waits.
Abstract
Forty-nine "standard" compounds known to be useful in the treatment of other diseases were tested for their suppressive activity against the trypomastigotes of Trypanosoma cruzi-infected mice. The most active was the antidepressant protriptyline, which was almost three times as effective as the reference drug, nifurtimox. A major value of the present data is to demonstrate the refractoriness of the T. cruzi parasite against many of the drug standards that have known biological activity.Entities:
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Year: 1997 PMID： 9402149 DOI： 10.3181/00379727-216-44192
Source DB: PubMed Journal: Proc Soc Exp Biol Med ISSN： 0037-9727