| Literature DB >> 940114 |
R B Brundrett, J W Cowens, M Colvin.
Abstract
BCNU-alpha-d4 [1,3-bis(2-chloro-1,1-dideuterioethyl)-1-nitrosourea] and BCNU-beta-d4 [1,3-bis(2-chloro-2,2-dideuterioethyl)-1-nitrosourea] were synthesized and decomposed in buffered (pH 7.4)water. The products were analyzed by GC-MS. The deuterium distribution in the products is inconsistent with vinylcarbonium ion or diazochloroethane intermediacy but is consistent with a 2-chloroethylcarbonium ion intermediate with some rearrangement to the 1-chloroethylcarbonium ion and the cyclic chloronium ion.Entities:
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Year: 1976 PMID： 940114 DOI： 10.1021/jm00229a019
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446