Literature DB >> 9400936

Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma.

I Bièche1, C Noguès, S Rivoilan, A Khodja, A Latil, R Lidereau.   

Abstract

To confirm several recent studies pointing to loss of heterozygosity (LOH) at BRCA2 as a prognostic factor in sporadic breast cancer, we examined this genetic alteration in a large series of human primary breast tumours for which long-term patient outcomes were known. LOH at BRCA2 correlated only with low oestrogen and progesterone receptor content. Univariate analysis of metastasis-free survival and overall survival (log-rank test) showed no link with BRCA2 status (P = 0.34, P = 0.29 respectively). LOH at BRCA2 does not therefore appear to be a major prognostic marker in sporadic breast cancer.

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Year:  1997        PMID： 9400936      PMCID： PMC2228174          DOI： 10.1038/bjc.1997.572

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  17 in total

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