Literature DB >> 9399947

Immunization against the agent of human granulocytic ehrlichiosis in a murine model.

W Sun1, J W IJdo, S R Telford, E Hodzic, Y Zhang, S W Barthold, E Fikrig.   

Abstract

The agent of human granulocytic ehrlichiosis (HGE) is a newly recognized tick-borne pathogen that resides within polymorphonuclear leukocytes. C3H/HeN mice can become infected with the agent of HGE (designated aoHGE) by syringe inoculation or tick-borne infection and develop transient neutropenia. They thereby partially mimic human disease and provide a model in which to study immunity to this microorganism. Mice vaccinated with lysates of purified aoHGE, or administered aoHGE antisera, were partially protected from both syringe- and tick-transmitted challenge with aoHGE. These data suggest that antibodies are sufficient to provide substantial, but not complete, immunity against aoHGE.

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Year:  1997        PMID： 9399947      PMCID： PMC508513          DOI： 10.1172/JCI119855

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  25 in total

1.  Cell-mediated immune responses of adults to vaccination, challenge with Rickettsia rickettsii, or both.

Authors:  J S Dumler; C L Wisseman; P Fiset; M L Clements
Journal:  Am J Trop Med Hyg       Date:  1992-02       Impact factor: 2.345

2.  Human granulocytic ehrlichiosis in Massachusetts.

Authors:  S R Telford; T J Lepore; P Snow; C K Warner; J E Dawson
Journal:  Ann Intern Med       Date:  1995-08-15       Impact factor: 25.391

3.  Protective immunity induced by 67 K outer membrane protein of phase I Coxiella burnetii in mice and guinea pigs.

Authors:  Y X Zhang; N Zhi; S R Yu; Q J Li; G Q Yu; X Zhang
Journal:  Acta Virol       Date:  1994-12       Impact factor: 1.162

4.  Some characteristics of heavy and light bands of Rickettsia prowazekii on Renografin gradients.

Authors:  B A Hanson; C L Wisseman; A Waddell; D J Silverman
Journal:  Infect Immun       Date:  1981-11       Impact factor: 3.441

5.  A peptide of Chlamydia trachomatis shown to be a primary T-cell epitope in vitro induces cell-mediated immunity in vivo.

Authors:  S C Knight; S Iqball; C Woods; A Stagg; M E Ward; M Tuffrey
Journal:  Immunology       Date:  1995-05       Impact factor: 7.397

6.  Murine T-cell response to native and recombinant protein antigens of Rickettsia tsutsugamushi.

Authors:  C J Hickman; C K Stover; S W Joseph; E V Oaks
Journal:  Infect Immun       Date:  1993-05       Impact factor: 3.441

7.  Human granulocytic ehrlichiosis in the upper Midwest United States. A new species emerging?

Authors:  J S Bakken; J S Dumler; S M Chen; M R Eckman; L L Van Etta; D H Walker
Journal:  JAMA       Date:  1994-07-20       Impact factor: 56.272

Review 8.  Ehrlichial diseases of humans: emerging tick-borne infections.

Authors:  J S Dumler; J S Bakken
Journal:  Clin Infect Dis       Date:  1995-05       Impact factor: 9.079

9.  Ixodes dammini as a potential vector of human granulocytic ehrlichiosis.

Authors:  P Pancholi; C P Kolbert; P D Mitchell; K D Reed; J S Dumler; J S Bakken; S R Telford; D H Persing
Journal:  J Infect Dis       Date:  1995-10       Impact factor: 5.226

Review 10.  Emergence of the ehrlichioses as human health problems.

Authors:  D H Walker; J S Dumler
Journal:  Emerg Infect Dis       Date:  1996 Jan-Mar       Impact factor: 6.883
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  36 in total

1.  Antibody-mediated elimination of the obligate intracellular bacterial pathogen Ehrlichia chaffeensis during active infection.

Authors:  G M Winslow; E Yager; K Shilo; E Volk; A Reilly; F K Chu
Journal:  Infect Immun       Date:  2000-04       Impact factor: 3.441

2.  Essential role for humoral immunity during Ehrlichia infection in immunocompetent mice.

Authors:  Eric Yager; Constantine Bitsaktsis; Bisweswar Nandi; Jere W McBride; Gary Winslow
Journal:  Infect Immun       Date:  2005-12       Impact factor: 3.441

Review 3.  Mechanisms of obligatory intracellular infection with Anaplasma phagocytophilum.

Authors:  Yasuko Rikihisa
Journal:  Clin Microbiol Rev       Date:  2011-07       Impact factor: 26.132

Review 4.  Human granulocytic anaplasmosis.

Authors:  Johan S Bakken; J Stephen Dumler
Journal:  Infect Dis Clin North Am       Date:  2015-06       Impact factor: 5.982

Review 5.  The role of CD8 T lymphocytes in rickettsial infections.

Authors:  David H Walker; J Stephen Dumler
Journal:  Semin Immunopathol       Date:  2015-04-01       Impact factor: 9.623

6.  Experimental infection of white-tailed deer with Anaplasma phagocytophilum, etiologic agent of human granulocytic anaplasmosis.

Authors:  Cynthia M Tate; Daniel G Mead; M Page Luttrell; Elizabeth W Howerth; Vivien G Dugan; Ulrike G Munderloh; William R Davidson
Journal:  J Clin Microbiol       Date:  2005-08       Impact factor: 5.948

7.  Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection.

Authors:  Bindu Sukumaran; Yasunori Ogura; Joao H F Pedra; Koichi S Kobayashi; Richard A Flavell; Erol Fikrig
Journal:  FEMS Immunol Med Microbiol       Date:  2012-07-23

8.  Serum cytokine responses during acute human granulocytic ehrlichiosis.

Authors:  J S Dumler; E R Trigiani; J S Bakken; M E Aguero-Rosenfeld; G P Wormser
Journal:  Clin Diagn Lab Immunol       Date:  2000-01

9.  Major histocompatibility complex class II DR-restricted memory CD4(+) T lymphocytes recognize conserved immunodominant epitopes of Anaplasma marginale major surface protein 1a.

Authors:  Wendy C Brown; Travis C McGuire; Waithaka Mwangi; Kimberly A Kegerreis; Henriette Macmillan; Harris A Lewin; Guy H Palmer
Journal:  Infect Immun       Date:  2002-10       Impact factor: 3.441

10.  Identification of Anaplasma phagocytophila (formerly Ehrlichia phagocytophila) variants in blood from sheep in Norway.

Authors:  Snorre Stuen; Ingrid Van De Pol; Karin Bergström; Leo M Schouls
Journal:  J Clin Microbiol       Date:  2002-09       Impact factor: 5.948
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