Literature DB >> 9399666

Folate-maytansinoids: target-selective drugs of low molecular weight.

C A Ladino1, R V Chari, L A Bourret, N L Kedersha, V S Goldmacher.   

Abstract

Folate receptor is over-expressed in a variety of carcinomas. To design a cytotoxic drug that would selectively target these carcinomas, we synthesized folate-maytansinoids. These drugs showed high affinity toward folate receptor, appeared to enter cells exclusively via the folate receptor-mediated caveolar pathway and displayed high cytotoxic potency (in the range of 10[-11] to 10[-10] M) and remarkable selectivity for folate receptor-expressing carcinoma cell lines. Folate-maytansinoids represent a new class of tumor-specific agents in which the targeting and the cytotoxic function can be altered independently.

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Year:  1997        PMID： 9399666     DOI： 10.1002/(sici)1097-0215(19971210)73:6<859::aid-ijc16>3.0.co;2-#

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  12 in total

1.  Quantification of endocytosis using a folate functionalized silica hollow nanoshell platform.

Authors:  Sergio Sandoval; Natalie Mendez; Jesus G Alfaro; Jian Yang; Sharraya Aschemeyer; Alex Liberman; William C Trogler; Andrew C Kummel
Journal:  J Biomed Opt       Date:  2015-08       Impact factor: 3.170

2.  In vitro and in vivo targeting of different folate receptor-positive cancer cell lines with a novel 99mTc-radiofolate tracer.

Authors:  Cristina Müller; P August Schubiger; Roger Schibli
Journal:  Eur J Nucl Med Mol Imaging       Date:  2006-05-24       Impact factor: 9.236

3.  Receptor-targeted gene delivery via folate-conjugated polyethylenimine.

Authors:  W Guo; R L Lee
Journal:  AAPS PharmSci       Date:  1999

4.  Preclinical evaluation of novel organometallic 99mTc-folate and 99mTc-pteroate radiotracers for folate receptor-positive tumour targeting.

Authors:  Cristina Müller; Alexander Hohn; P August Schubiger; Roger Schibli
Journal:  Eur J Nucl Med Mol Imaging       Date:  2006-06-09       Impact factor: 9.236

5.  Examining expression of folate receptor in squamous cell carcinoma of the head and neck as a target for a novel nanotherapeutic drug.

Authors:  Nabil F Saba; Xu Wang; Susan Müller; Mourad Tighiouart; Kwangjae Cho; Shuming Nie; Zhuo Chen; Dong M Shin
Journal:  Head Neck       Date:  2009-04       Impact factor: 3.147

6.  Evaluation of a novel radiofolate in tumour-bearing mice: promising prospects for folate-based radionuclide therapy.

Authors:  Cristina Müller; Thomas L Mindt; Marion de Jong; Roger Schibli
Journal:  Eur J Nucl Med Mol Imaging       Date:  2009-01-30       Impact factor: 9.236

7.  The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.

Authors:  Tin-Wein Yu; Linquan Bai; Dorothee Clade; Dietmar Hoffmann; Sabine Toelzer; Khue Q Trinh; Jun Xu; Steven J Moss; Eckhard Leistner; Heinz G Floss
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-11       Impact factor: 11.205

8.  Folate receptor-mediated enhanced and specific delivery of far-red light-activatable prodrugs of combretastatin A-4 to FR-positive tumor.

Authors:  Gregory Nkepang; Moses Bio; Pallavi Rajaputra; Samuel G Awuah; Youngjae You
Journal:  Bioconjug Chem       Date:  2014-11-21       Impact factor: 4.774

Review 9.  Advances in targeting the folate receptor in the treatment/imaging of cancers.

Authors:  Marcos Fernández; Faiza Javaid; Vijay Chudasama
Journal:  Chem Sci       Date:  2017-12-18       Impact factor: 9.825

Review 10.  Targeted drug delivery via folate receptors in recurrent ovarian cancer: a review.

Authors:  Claudia Marchetti; Innocenza Palaia; Margherita Giorgini; Caterina De Medici; Roberta Iadarola; Laura Vertechy; Lavinia Domenici; Violante Di Donato; Federica Tomao; Ludovico Muzii; Pierluigi Benedetti Panici
Journal:  Onco Targets Ther       Date:  2014-07-10       Impact factor: 4.147
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