| Literature DB >> 9399601 |
T M Sievers1, S J Rossi, R M Ghobrial, E Arriola, P Nishimura, M Kawano, C D Holt.
Abstract
Mycophenolate mofetil is the morpholinoethylester prodrug of mycophenolic acid, an agent that inhibits the proliferation of B and T lymphocytes through noncompetitive, reversible inhibition of inosine monophosphate dehydrogenase, a key enzyme in the de novo synthetic pathway of guanine nucleotides. Currently, mycophenolate mofetil is approved for the prevention of acute renal allograft rejection when given in combination with cyclosporine and steroids. Several studies also demonstrated that the agent is effective in the treatment of refractory rejection in renal, heart, and liver transplant recipients, and may have efficacy in the treatment of chronic rejection as well.Entities:
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Year: 1997 PMID： 9399601
Source DB: PubMed Journal: Pharmacotherapy ISSN： 0277-0008 Impact factor: 4.705