Literature DB >> 93986

Physiologically based pharmacokinetic models for anticancer drugs.

H S Chen, J F Gross.   

Abstract

The rationale and history of the development of physiologically based pharmacokinetic models are briefly reviewed in this paper. The methods of model construction and the previous application of this type of model to anticancer drugs are discussed. Future research should be focused on the following areas: (1) interspecies scaling, (2) the effects of disease states on the pharmacokinetics of anticancer drugs, and (3) the applications of pharmocokinetics to the studies of growth behavior of cancer cells. The ultimate goal will be to utilize this basic information to design an optimal dosage regimen and treatment schedule for the safe and effective cancer chemotherapy of each individual patient.

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Year:  1979        PMID： 93986     DOI： 10.1007/bf00254079

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  40 in total

1.  Disposition of cytosine arabinoside (NSC-63878) and its metabolites: a pharmacokinetic simulation.

Authors:  P F Morrison; T L Lincoln; J Aroesty
Journal:  Cancer Chemother Rep       Date:  1975 Jul-Aug

2.  Interaction between the circulatory effects and the uptake and disribution of halothane: use of a multiple model.

Authors:  N T Smith; A Zwart; J E Beneken
Journal:  Anesthesiology       Date:  1972-07       Impact factor: 7.892

3.  Multiple model approach to uptake and distribution of halothane: the use of an analog computer.

Authors:  A Zwart; N T Smith; J E Beneken
Journal:  Comput Biomed Res       Date:  1972-06

4.  Thiopental pharmacokinetics.

Authors:  K B Bischoff; R L Dedrick
Journal:  J Pharm Sci       Date:  1968-08       Impact factor: 3.534

5.  Methotrexate tissue distribution: prediction by a mathematical model.

Authors:  D S Zaharko; R L Dedrick; K B Bischoff; J A Longstreth; V T Oliverio
Journal:  J Natl Cancer Inst       Date:  1971-04       Impact factor: 13.506

6.  Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer.

Authors:  R L Dedrick; C E Myers; P M Bungay; V T DeVita
Journal:  Cancer Treat Rep       Date:  1978-01

7.  Lidocaine disposition kinetics in monkey and man. I. Prediction by a perfusion model.

Authors:  N Benowitz; F P Forsyth; K L Melmon; M Rowland
Journal:  Clin Pharmacol Ther       Date:  1974-07       Impact factor: 6.875

8.  Pharmacokinetic model for salicyclate in cerebrospinal fluid, blood, organs, and tissues.

Authors:  C N Chen; D L Coleman; J D Andrade; A R Temple
Journal:  J Pharm Sci       Date:  1978-01       Impact factor: 3.534

9.  The kinetics of methotrexate distribution in spontaneous canine lymphosarcoma.

Authors:  R J Lutz; R L Dedrick; J A Straw; M M Hart; P Klubes; D S Zaharko
Journal:  J Pharmacokinet Biopharm       Date:  1975-04

10.  Pharmacokinetics of 1-beta-D-arabinofuranosylcytosine (ARA-C) deamination in several species.

Authors:  R L Dedrick; D D Forrester; J N Cannon; S M el-Dareer; L B Mellett
Journal:  Biochem Pharmacol       Date:  1973-10-01       Impact factor: 5.858
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  20 in total

Review 1.  Whole body pharmacokinetic models.

Authors:  Ivan Nestorov
Journal:  Clin Pharmacokinet       Date:  2003       Impact factor: 6.447

2.  Synthesis and biodistribution of Bowman-Birk soybean protease inhibitor conjugate with amphiphilic polyester.

Authors:  N I Larionova; I P Gladysheva; O V Polekhina; L P Kurochkina; E N Gorbatova
Journal:  Appl Biochem Biotechnol       Date:  1996 Oct-Nov       Impact factor: 2.926

3.  Adrenergic stimulation of the rat mesenteric vascular bed: a combined micro- and macrocirculatory study.

Authors:  L M Le Noble; G J Tangelder; D W Slaaf; J F Smits; H A Struyker-Boudier
Journal:  Pflugers Arch       Date:  1987-10       Impact factor: 3.657

4.  Physiological pharmacokinetics.

Authors:  K B Bischoff
Journal:  Bull Math Biol       Date:  1986       Impact factor: 1.758

5.  Evaluation of cytostatic drug concentrations in the kidney, bladder wall, and prostate by means of the diffusion chamber technique in dogs.

Authors:  P Porpaczy; C P Schmidbauer; A Georgopoulos; H Rameis; T A Endler
Journal:  Urol Res       Date:  1983

6.  Pharmacokinetics of high-dose methotrexate in dogs. An experimental model with diffusion chambers.

Authors:  P Porpaczy; C P Schmidbauer; A Georgopoulos; A T Endler
Journal:  Cancer Chemother Pharmacol       Date:  1983       Impact factor: 3.333

7.  Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model.

Authors:  Y Igari; Y Sugiyama; Y Sawada; T Iga; M Hanano
Journal:  J Pharmacokinet Biopharm       Date:  1983-12

8.  Phase I trials in clinical oncostatic pharmacology.

Authors:  P Ribaud; G Mathé
Journal:  Cancer Chemother Pharmacol       Date:  1980       Impact factor: 3.333

9.  Comparative physiologically based pharmacokinetics of hexobarbital, phenobarbital and thiopental in the rat.

Authors:  Y Igari; Y Sugiyama; S Awazu; M Hanano
Journal:  J Pharmacokinet Biopharm       Date:  1982-02

Review 10.  Systems engineering medicine: engineering the inflammation response to infectious and traumatic challenges.

Authors:  Robert S Parker; Gilles Clermont
Journal:  J R Soc Interface       Date:  2010-02-10       Impact factor: 4.118
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