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Literature DB >> 9398014

Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver.

P J Meier¹, U Eckhardt, A Schroeder, B Hagenbuch, B Stieger.

Abstract

The Na+-dependent bile salt uptake systems Ntcp (rodents) and NTCP (human), and the Na+-independent organic anion transporters oatpl (rat) and OATP (human) mediate sinusoidal uptake of a variety of amphipathic organic compounds into hepatocytes. Their properties indicate that an overall hepatic clearance of albumin-bound compounds is mediated by a limited number of multispecific transporters with partially overlapping substrate specificities.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 1997 PMID： 9398014 DOI： 10.1002/hep.510260641

Source DB: PubMed Journal: Hepatology ISSN： 0270-9139 Impact factor: 17.425

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Cited

47 in total

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