Literature DB >> 9397683

The DNA polymerase alpha-primase complex couples DNA replication, cell-cycle progression and DNA-damage response.

M Foiani1, G Lucchini, P Plevani.   

Abstract

The highly conserved DNA polymerase alpha-primase complex (pol-prism) is the only eukaryotic DNA polymerase that can initiate DNA synthesis de novo. It is required both for the initiation of DNA replication at chromosomal origins and for the discontinuous synthesis of Okazaki fragments on the lagging strand of the replication fork. The dual role of pol-prim makes it a likely target for mechanisms that control cell-cycle S-phase entry and progression.

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Year:  1997        PMID： 9397683     DOI： 10.1016/s0968-0004(97)01109-2

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  22 in total

1.  Cloning and characterization of the 5'-upstream sequence governing the cell cycle-dependent transcription of mouse DNA polymerase alpha 68 kDa subunit gene.

Authors:  N S Nishikawa; M Izumi; H Uchida; M Yokoi; H Miyazawa; F Hanaoka
Journal:  Nucleic Acids Res       Date:  2000-04-01       Impact factor: 16.971

2.  Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling.

Authors:  J M Angelastro; L Klimaschewski; S Tang; O V Vitolo; T A Weissman; L T Donlin; M L Shelanski; L A Greene
Journal:  Proc Natl Acad Sci U S A       Date:  2000-09-12       Impact factor: 11.205

Review 3.  Okazaki fragment maturation: nucleases take centre stage.

Authors:  Li Zheng; Binghui Shen
Journal:  J Mol Cell Biol       Date:  2011-02       Impact factor: 6.216

4.  Role of the p68 subunit of human DNA polymerase alpha-primase in simian virus 40 DNA replication.

Authors:  Robert D Ott; Christoph Rehfuess; Vladimir N Podust; Jill E Clark; Ellen Fanning
Journal:  Mol Cell Biol       Date:  2002-08       Impact factor: 4.272

5.  Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase.

Authors:  Sivaraja Vaithiyalingam; Eric M Warren; Brandt F Eichman; Walter J Chazin
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-19       Impact factor: 11.205

6.  Cyclin B-cdk1 kinase stimulates ORC- and Cdc6-independent steps of semiconservative plasmid replication in yeast nuclear extracts.

Authors:  B P Duncker; P Pasero; D Braguglia; P Heun; M Weinreich; S M Gasser
Journal:  Mol Cell Biol       Date:  1999-02       Impact factor: 4.272

7.  Srs2 DNA helicase is involved in checkpoint response and its regulation requires a functional Mec1-dependent pathway and Cdk1 activity.

Authors:  G Liberi; I Chiolo; A Pellicioli; M Lopes; P Plevani; M Muzi-Falconi; M Foiani
Journal:  EMBO J       Date:  2000-09-15       Impact factor: 11.598

8.  Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast.

Authors:  H Masumoto; A Sugino; H Araki
Journal:  Mol Cell Biol       Date:  2000-04       Impact factor: 4.272

9.  Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases.

Authors:  T Tanaka; K Nasmyth
Journal:  EMBO J       Date:  1998-09-01       Impact factor: 11.598

10.  Reducing DNA polymerase alpha in the absence of Drosophila ATR leads to P53-dependent apoptosis and developmental defects.

Authors:  Jeannine R LaRocque; Diana L Dougherty; Sumreen K Hussain; Jeff Sekelsky
Journal:  Genetics       Date:  2007-05-04       Impact factor: 4.562
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