Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A CTD function linking transcription to splicing.

Literature DB >> 9397679

A CTD function linking transcription to splicing.

Abstract

Since its discovery in 1985, the function of the C-terminal domain (CTD) of RNA polymerase II has been a puzzle. Recent studies suggest that the CTD functions as a linear platform for assembly of complexes that splice, cleave and polyadenylate pre-mRNA. A new set of CTD-associated SR-like proteins (CASPs) have been implicated in pre-mRNA processing and transcription elongation as a component of the emerging 'transcriptosome'.

Mesh：

Substances：

Year: 1997 PMID： 9397679 DOI： 10.1016/s0968-0004(97)01125-0

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

Keyword Cloud
Cited

65 in total

1. The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn).

Authors: A M Hartmann; O Nayler; F W Schwaiger; A Obermeier; S Stamm
Journal: Mol Biol Cell Date: 1999-11 Impact factor: 4.138

A CTD function linking transcription to splicing.

1. The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn).

Review 2. Spatial organization of RNA polymerase II transcription in the nucleus.

3. Nuclear pre-mRNA compartmentalization: trafficking of released transcripts to splicing factor reservoirs.

4. Prespliceosomal assembly on microinjected precursor mRNA takes place in nuclear speckles.

5. Participation of the C-terminal domain of RNA polymerase II in exon definition during pre-mRNA splicing.

6. Amino acid repeat patterns in protein sequences: their diversity and structural-functional implications.

7. Evolution of the RNA polymerase II C-terminal domain.

8. In situ transcription and splicing in the Balbiani ring 3 gene.

9. Epstein-Barr virus nuclear antigen 5 inhibits pre-mRNA cleavage and polyadenylation.

10. A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.