OBJECTIVE: Our purpose was to determine in a randomized, placebo-controlled manner whether multiple antenatal doses of betamethasone affect long-term growth and development of exposed mouse offspring. STUDY DESIGN: Sixty pregnant CD-1 mice received either two, four, or eight antepartum doses of 0.1 mg betamethasone or placebo. Perinatal outcomes, growth, and development of the offspring were compared in a blinded manner. Variables were compared by analysis of variance or chi 2 testing. RESULTS: Betamethasone-exposed subjects gained less weight during pregnancy and were delivered of fewer live pups, with fewer male survivors and lower birth weights. These trends were dose related. Growth measurements were similar after the neonatal period. No differences in functional development and physical maturation in the offspring were noted. The reproductive capability, perinatal outcomes, and growth and development of the second-generation offspring were unaffected by betamethasone exposure. CONCLUSION: Multiple antenatal dosings of betamethasone, reaching toxic levels, did not have an impact on the long-term growth and development of the surviving mouse offspring.
OBJECTIVE: Our purpose was to determine in a randomized, placebo-controlled manner whether multiple antenatal doses of betamethasone affect long-term growth and development of exposed mouse offspring. STUDY DESIGN: Sixty pregnant CD-1mice received either two, four, or eight antepartum doses of 0.1 mg betamethasone or placebo. Perinatal outcomes, growth, and development of the offspring were compared in a blinded manner. Variables were compared by analysis of variance or chi 2 testing. RESULTS:Betamethasone-exposed subjects gained less weight during pregnancy and were delivered of fewer live pups, with fewer male survivors and lower birth weights. These trends were dose related. Growth measurements were similar after the neonatal period. No differences in functional development and physical maturation in the offspring were noted. The reproductive capability, perinatal outcomes, and growth and development of the second-generation offspring were unaffected by betamethasone exposure. CONCLUSION: Multiple antenatal dosings of betamethasone, reaching toxic levels, did not have an impact on the long-term growth and development of the surviving mouse offspring.
Authors: Anna Maria Marconi; Valentina Mariotti; Cecilia Teng; Stefania Ronzoni; Barbara D'Amato; Alberto Morabito; Frederick C Battaglia Journal: Am J Obstet Gynecol Date: 2009-12-21 Impact factor: 8.661
Authors: Lindsay S Cahill; Clare L Whitehead; Sebastian R Hobson; Greg Stortz; John C Kingdom; Ahmet Baschat; Kellie E Murphy; Lena Serghides; Christopher K Macgowan; John G Sled Journal: Biol Reprod Date: 2019-10-25 Impact factor: 4.285
Authors: Elaine L Shelton; Nahid Waleh; Erin J Plosa; John T Benjamin; Ginger L Milne; Christopher W Hooper; Noah J Ehinger; Stanley Poole; Naoko Brown; Steven Seidner; Donald McCurnin; Jeff Reese; Ronald I Clyman Journal: Pediatr Res Date: 2018-07-06 Impact factor: 3.756