Literature DB >> 9396737

Glycosylphosphatidylinositols of Plasmodium chabaudi chabaudi: a basis for the study of malarial glycolipid toxins in a rodent model.

P Gerold1, L Vivas, S A Ogun, N Azzouz, K N Brown, A A Holder, R T Schwarz.   

Abstract

Free and protein-bound glycosylphosphatidylinositols (GPIs) of the blood stages of the rodent malarial parasite Plasmodium chabaudi chabaudi AS were identified and characterized. TLC analysis of material extracted by organic solvents from metabolically labelled parasites revealed a distinct set of glycolipids. These glycolipids were identified as GPIs by specific chemical and enzymic treatments and by structural analysis of their glycan and hydrophobic parts. These analyses revealed that P.c.chabaudi AS synthesizes a set of GPI-biosynthesis intermediates and two potential GPI-anchor precursors exhibiting the following structures: ethanolamine-phosphate [(alpha1-2)mannose]mannose (alpha 1-2) mannose (alpha 1-6) mannose (alpha 1-4) glucosamine - (acyl) inositol-phosphate-diacylglycerol (P.ch. alpha) and ethanolamine-phosphate - mannose (alpha 1-2) mannose (alpha 1-6) mannose (alpha 1-4) glucosamine-(acyl)inositol-phosphate-diacylglycerol (P.ch. beta). One of these GPI-anchor precursors (P.ch. alpha) possesses the same carbohydrate structure as the GPI membrane anchor of merozoite surface protein-1 from P.c.chabaudi AS.

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Year:  1997        PMID： 9396737      PMCID： PMC1219003          DOI： 10.1042/bj3280905

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  23 in total

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Authors:  M J McConville; M A Ferguson
Journal:  Biochem J       Date:  1993-09-01       Impact factor: 3.857

2.  The establishment of genomic DNA libraries for the human malaria parasite Plasmodium falciparum and identification of individual clones by hybridisation.

Authors:  M Goman; G Langsley; J E Hyde; N K Yankovsky; J W Zolg; J G Scaife
Journal:  Mol Biochem Parasitol       Date:  1982-06       Impact factor: 1.759

3.  Malaria, blood glucose, and the role of tumour necrosis factor (TNF) in mice.

Authors:  K M Elased; J Taverne; J H Playfair
Journal:  Clin Exp Immunol       Date:  1996-09       Impact factor: 4.330

4.  Analysis of the neutral glycan fractions of glycosyl-phosphatidylinositols by thin-layer chromatography.

Authors:  P Schneider; J E Ralton; M J McConville; M A Ferguson
Journal:  Anal Biochem       Date:  1993-04       Impact factor: 3.365

5.  Glycosylphosphatidylinositol toxin of Plasmodium up-regulates intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin expression in vascular endothelial cells and increases leukocyte and parasite cytoadherence via tyrosine kinase-dependent signal transduction.

Authors:  L Schofield; S Novakovic; P Gerold; R T Schwarz; M J McConville; S D Tachado
Journal:  J Immunol       Date:  1996-03-01       Impact factor: 5.422

6.  Glycosylphosphatidylinositol toxin of Plasmodium induces nitric oxide synthase expression in macrophages and vascular endothelial cells by a protein tyrosine kinase-dependent and protein kinase C-dependent signaling pathway.

Authors:  S D Tachado; P Gerold; M J McConville; T Baldwin; D Quilici; R T Schwarz; L Schofield
Journal:  J Immunol       Date:  1996-03-01       Impact factor: 5.422

7.  Nucleotide sequence analysis and epitope mapping of the merozoite surface protein 1 from Plasmodium chabaudi chabaudi AS.

Authors:  P G McKean; K O'Dea; K N Brown
Journal:  Mol Biochem Parasitol       Date:  1993-12       Impact factor: 1.759

Review 8.  GPI-anchor biosynthesis.

Authors:  J Takeda; T Kinoshita
Journal:  Trends Biochem Sci       Date:  1995-09       Impact factor: 13.807

Review 9.  Malaria pathogenesis.

Authors:  L H Miller; M F Good; G Milon
Journal:  Science       Date:  1994-06-24       Impact factor: 47.728

10.  Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites.

Authors:  L Schofield; F Hackett
Journal:  J Exp Med       Date:  1993-01-01       Impact factor: 14.307
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  2 in total

1.  Prevalence and boosting of antibodies to Plasmodium falciparum glycosylphosphatidylinositols and evaluation of their association with protection from mild and severe clinical malaria.

Authors:  J Brian de Souza; James Todd; Gowdahalli Krishegowda; D Channe Gowda; Dominic Kwiatkowski; Eleanor M Riley
Journal:  Infect Immun       Date:  2002-09       Impact factor: 3.441

2.  Fetal and Maternal Innate Immunity Receptors Have Opposing Effects on the Severity of Experimental Malaria in Pregnancy: Beneficial Roles for Fetus-Derived Toll-Like Receptor 4 and Type I Interferon Receptor 1.

Authors:  Lurdes Rodrigues-Duarte; Yash Pandya; Rita Neres; Carlos Penha-Gonçalves
Journal:  Infect Immun       Date:  2018-04-23       Impact factor: 3.441
  2 in total

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