Literature DB >> 9395395

Role of inositol 1,4,5-trisphosphate receptor in ventral signaling in Xenopus embryos.

S Kume1, A Muto, T Inoue, K Suga, H Okano, K Mikoshiba.   

Abstract

The inositol 1,4,5-trisphosphate (IP3) receptor is a calcium ion channel involved in the release of free Ca2+ from intracellular stores. For analysis of the role of IP3-induced Ca2+ release (IICR) on patterning of the embryonic body, monoclonal antibodies that inhibit IICR were produced. Injection of these blocking antibodies into the ventral part of early Xenopus embryos induced modest dorsal differentiation. A close correlation between IICR blocking potencies and ectopic dorsal axis induction frequency suggests that an active IP3-Ca2+ signal may participate in the modulation of ventral differentiation.

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Year:  1997        PMID： 9395395     DOI： 10.1126/science.278.5345.1940

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  25 in total

1.  Statistical evaluation of differential expression on cDNA nylon arrays with replicated experiments.

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Journal:  Nucleic Acids Res       Date:  2001-12-01       Impact factor: 16.971

2.  Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening.

Authors:  Haruka Yamazaki; Jenny Chan; Mitsuhiko Ikura; Takayuki Michikawa; Katsuhiko Mikoshiba
Journal:  J Biol Chem       Date:  2010-09-02       Impact factor: 5.157

3.  Xenopus embryos and ES cells as tools for studies of developmental biology.

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4.  xBtg-x regulates Wnt/beta-Catenin signaling during early Xenopus development.

Authors:  Oliver Wessely; James I Kim; Uyen Tran; Luis Fuentealba; E M De Robertis
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Review 5.  Calcium at fertilization and in early development.

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Authors:  J Ramos-Franco; M Fill; G A Mignery
Journal:  Biophys J       Date:  1998-08       Impact factor: 4.033

7.  Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/beta -catenin-regulated cell proliferation.

Authors:  Guangnan Li; Ravi Iyengar
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-18       Impact factor: 11.205

8.  The Xenopus oocyte: a single-cell model for studying Ca2+ signaling.

Authors:  Yaping Lin-Moshier; Jonathan S Marchant
Journal:  Cold Spring Harb Protoc       Date:  2013-03-01

9.  Metabolite regulation of the mitochondrial calcium uniporter channel.

Authors:  Dhanendra Tomar; John W Elrod
Journal:  Cell Calcium       Date:  2020-09-11       Impact factor: 6.817

10.  Lrmp/Jaw1 is expressed in sweet, bitter, and umami receptor-expressing cells.

Authors:  Yoichiro Shindo; Mi-Ryung Kim; Hirohito Miura; Toshifumi Yuuki; Tomomasa Kanda; Akihiro Hino; Yuko Kusakabe
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