Literature DB >> 9395080

The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase.

E Rosengren1, P Aman, S Thelin, C Hansson, S Ahlfors, P Björk, L Jacobsson, H Rorsman.   

Abstract

A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.

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Year:  1997        PMID： 9395080     DOI： 10.1016/s0014-5793(97)01261-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  62 in total

1.  Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.

Authors:  Yoonsang Cho; Gregg V Crichlow; Jon J Vermeire; Lin Leng; Xin Du; Michael E Hodsdon; Richard Bucala; Michael Cappello; Matt Gross; Federico Gaeta; Kirk Johnson; Elias J Lolis
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-08       Impact factor: 11.205

Review 2.  Macrophage migration inhibitory factor as a therapeutic target after traumatic spinal cord injury: a systematic review.

Authors:  Seyed Mohammad Piri; Zahra Ghodsi; Sina Shool; Ali Anjomshoa; Amir Azarhomayoun; Ehsan Jangholi; Hamid Reza Dehghan; Rasha Atlasi; Alexander R Vaccaro; Vafa Rahimi-Movaghar
Journal:  Eur Spine J       Date:  2021-01-24       Impact factor: 3.134

3.  Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for anti-inflammatory intervention.

Authors:  Zachary R Healy; Hua Liu; W David Holtzclaw; Paul Talalay
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2011-05-20       Impact factor: 4.254

4.  Charge heterogeneity of bovine brain macrophage migration inhibitory factor.

Authors:  O A Cherepkova; E M Lutova; B Ya Gurvits
Journal:  Neurochem Res       Date:  2005-01       Impact factor: 3.996

5.  Filarial nematode parasites secrete a homologue of the human cytokine macrophage migration inhibitory factor.

Authors:  D V Pastrana; N Raghavan; P FitzGerald; S W Eisinger; C Metz; R Bucala; R P Schleimer; C Bickel; A L Scott
Journal:  Infect Immun       Date:  1998-12       Impact factor: 3.441

6.  Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates.

Authors:  Kristin K Brown; Frances H Blaikie; Robin A J Smith; Joel D A Tyndall; Hongqi Lue; Jürgen Bernhagen; Christine C Winterbourn; Mark B Hampton
Journal:  J Biol Chem       Date:  2009-09-23       Impact factor: 5.157

7.  Rapid purification and characterization of L-dopachrome-methyl ester tautomerase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi.

Authors:  J L Pennock; J M Behnke; Q D Bickle; E Devaney; R K Grencis; R E Isaac; G W Joshua; M E Selkirk; Y Zhang; D J Meyer
Journal:  Biochem J       Date:  1998-11-01       Impact factor: 3.857

8.  A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation.

Authors:  Günter Fingerle-Rowson; Dayananda Rao Kaleswarapu; Corinna Schlander; Nazanin Kabgani; Tania Brocks; Nina Reinart; Raymonde Busch; Anke Schütz; Hongqi Lue; Xin Du; Aihua Liu; Huabao Xiong; Yibang Chen; Alice Nemajerova; Michael Hallek; Jürgen Bernhagen; Lin Leng; Richard Bucala
Journal:  Mol Cell Biol       Date:  2009-02-02       Impact factor: 4.272

Review 9.  Mechanisms of macrophage migration inhibitory factor (MIF)-dependent tumor microenvironmental adaptation.

Authors:  Beatriz E Rendon; Sharon S Willer; Wayne Zundel; Robert A Mitchell
Journal:  Exp Mol Pathol       Date:  2009-01-07       Impact factor: 3.362

Review 10.  The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings.

Authors:  Garry G Graham; Michael J Davies; Richard O Day; Anthoulla Mohamudally; Kieran F Scott
Journal:  Inflammopharmacology       Date:  2013-05-30       Impact factor: 4.473
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