| Literature DB >> 9393859 |
M Kondo1, I L Weissman, K Akashi.
Abstract
The existence of a common lymphoid progenitor that can only give rise to T cells, B cells, and natural killer (NK) cells remains controversial and constitutes an important gap in the hematopoietic lineage maps. Here, we report that the Lin(-)IL-7R(+)Thy-1(-)Sca-1loc-Kit(lo) population from adult mouse bone marrow possessed a rapid lymphoid-restricted (T, B, and NK) reconstitution capacity in vivo but completely lacked myeloid differentiation potential either in vivo or in vitro. A single Lin(-)IL-7R(+)Thy-1(-)Sca-1loc-Kit(lo) cell could generate at least both T and B cells. These data provide direct evidence for the existence of common lymphoid progenitors in sites of early hematopoiesis.Entities:
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Year: 1997 PMID： 9393859 DOI： 10.1016/s0092-8674(00)80453-5
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582