Literature DB >> 9393843

Association of Leishmania heat shock protein 83 antigen and immunoglobulin G4 antibody titers in Brazilian patients with diffuse cutaneous leishmaniasis.

Y A Skeiky1, D R Benson, J L Costa, R Badaro, S G Reed.   

Abstract

Diffuse cutaneous leishmaniasis (DCL) is characterized by the presence of numerous nonulcerated nodules and plaques containing large numbers of Leishmania amazonensis parasites and few lymphoid elements. The immune responses of DCL patients reflect severe antigen-specific T-cell deficiencies, while the antibody response to Leishmania antigens is often accentuated. We report herein on the Leishmania antigen-specific antibody subclass distribution in DCL patients and demonstrate that a dominant antigen contributing to the biased immunoglobulin G4 antibody subclass in sera of DCL patients is Leishmania heat shock protein 83.

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Year:  1997        PMID： 9393843      PMCID： PMC175776          DOI： 10.1128/iai.65.12.5368-5370.1997

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  26 in total

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Journal:  J Infect Dis       Date:  1987-07       Impact factor: 5.226

Review 5.  The American leishmaniases: some observations on their ecology and epidemiology.

Authors:  R Lainson
Journal:  Trans R Soc Trop Med Hyg       Date:  1983       Impact factor: 2.184

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Journal:  Nature       Date:  1988-07-21       Impact factor: 49.962

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Journal:  Clin Immunol Immunopathol       Date:  1983-05

8.  Possible role of human lymphocyte receptor for IgE (CD23) or its soluble fragments in the in vitro synthesis of human IgE.

Authors:  M Sarfati; G Delespesse
Journal:  J Immunol       Date:  1988-10-01       Impact factor: 5.422

9.  IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2.

Authors:  J Pène; F Rousset; F Brière; I Chrétien; J Y Bonnefoy; H Spits; T Yokota; N Arai; K Arai; J Banchereau
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

10.  Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones.

Authors:  H Gascan; J F Gauchat; M G Roncarolo; H Yssel; H Spits; J E de Vries
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  6 in total

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Journal:  Infect Immun       Date:  1999-12       Impact factor: 3.441

2.  Immunoglobulin subclass distribution and diagnostic value of Leishmania donovani antigen-specific immunoglobulin G3 in Indian kala-azar patients.

Authors:  K Anam; F Afrin; D Banerjee; N Pramanik; S K Guha; R P Goswami; P N Gupta; S K Saha; N Ali
Journal:  Clin Diagn Lab Immunol       Date:  1999-03

3.  ELISA and western blotting for the detection of Hsp70 and Hsp83 antigens of Leishmania donovani.

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4.  Epitope mapping of the HSP83.1 protein of Leishmania braziliensis discloses novel targets for immunodiagnosis of tegumentary and visceral clinical forms of leishmaniasis.

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Journal:  Clin Vaccine Immunol       Date:  2014-05-07

5.  Adjuvants for Leishmania vaccines: from models to clinical application.

Authors:  Vanitha S Raman; Malcolm S Duthie; Christopher B Fox; Greg Matlashewski; Steven G Reed
Journal:  Front Immunol       Date:  2012-06-11       Impact factor: 7.561

6.  Towards a more precise serological diagnosis of human tegumentary leishmaniasis using Leishmania recombinant proteins.

Authors:  Ana Paula Souza; Manuel Soto; Jackson M L Costa; Viviane S Boaventura; Camila I de Oliveira; Juqueline R Cristal; Manoel Barral-Netto; Aldina Barral
Journal:  PLoS One       Date:  2013-06-12       Impact factor: 3.240
  6 in total

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