Literature DB >> 9392889

Antimycobacterial polyynes of Devil's Club (Oplopanax horridus), a North American native medicinal plant.

M Kobaisy1, Z Abramowski, L Lermer, G Saxena, R E Hancock, G H Towers, D Doxsee, R W Stokes.   

Abstract

Two new (3 and 5), as well as three known (1, 2, and 4), polyynes were isolated from Devil's Club (Oplopanax horridus; Araliaceae), a medicinal plant of North America. The structures were established by 1H and 13C NMR. The absolute configurations of 2 and 5 were determined by application of Mosher's method. All the polyynes exhibited significant anti-Candida, antibacterial, and antimycobacterial activity, with an ability to kill Mycobacterium tuberculosis and isoniazid-resistant Mycobacterium avium at 10 micrograms/disk in a disk diffusion assay.

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Year:  1997        PMID： 9392889     DOI： 10.1021/np970182j

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  22 in total

1.  Hydrophobic constituents and their potential anticancer activities from Devil's Club (Oplopanax horridus Miq.).

Authors:  Shi Sun; Guang-Jian Du; Lian-Wen Qi; Stainley Williams; Chong-Zhi Wang; Chun-Su Yuan
Journal:  J Ethnopharmacol       Date:  2010-08-17       Impact factor: 4.360

2.  Effects of Oplopanax horridus on human colorectal cancer cells.

Authors:  Xiao-Li Li; Shi Sun; Guang-Jian Du; Lian-Wen Qi; Stainley Williams; Chong-Zhi Wang; Chun-Su Yuan
Journal:  Anticancer Res       Date:  2010-02       Impact factor: 2.480

3.  Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis.

Authors:  Shixin Deng; Shao-Nong Chen; Ping Yao; Dejan Nikolic; Richard B van Breemen; Judy L Bolton; Harry H S Fong; Norman R Farnsworth; Guido F Pauli
Journal:  J Nat Prod       Date:  2006-04       Impact factor: 4.050

4.  Anti-oxidative and anti-inflammatory activities of devil's club (Oplopanax horridus) leaves.

Authors:  Mi Jang; Young-Chul Lee; Hee-Do Hong; Young Kyoung Rhee; Tae-Gyu Lim; Kyung-Tack Kim; Feng Chen; Hyun-Jin Kim; Chang-Won Cho
Journal:  Food Sci Biotechnol       Date:  2017-02-28       Impact factor: 2.391

Review 5.  Chemical and pharmacological studies of Oplopanax horridus, a North American botanical.

Authors:  Tyler Calway; Guang-Jian Du; Chong-Zhi Wang; Wei-Hua Huang; Jing Zhao; Shao-Ping Li; Chun-Su Yuan
Journal:  J Nat Med       Date:  2011-11-20       Impact factor: 2.343

6.  Catalytic Z-selective cross-metathesis with secondary silyl- and benzyl-protected allylic ethers: mechanistic aspects and applications to natural product synthesis.

Authors:  Tyler J Mann; Alexander W H Speed; Richard R Schrock; Amir H Hoveyda
Journal:  Angew Chem Int Ed Engl       Date:  2013-06-21       Impact factor: 15.336

7.  Anti-TB polyynes from the roots of Angelica sinensis.

Authors:  Shixin Deng; Yuehong Wang; Taichi Inui; Shao-Nong Chen; Norman R Farnsworth; Sanghyun Cho; Scott G Franzblau; Guido F Pauli
Journal:  Phytother Res       Date:  2008-07       Impact factor: 5.878

Review 8.  Biosynthesis and function of polyacetylenes and allied natural products.

Authors:  Robert E Minto; Brenda J Blacklock
Journal:  Prog Lipid Res       Date:  2008-03-13       Impact factor: 16.195

9.  Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors.

Authors:  Zhongze Ma; Wei Xu; Lee-Yuan Liu-Chen; David Y W Lee
Journal:  Bioorg Med Chem       Date:  2007-12-31       Impact factor: 3.641

10.  Differential effects of falcarinol and related aliphatic C(17)-polyacetylenes on intestinal cell proliferation.

Authors:  Stig Purup; Eric Larsen; Lars P Christensen
Journal:  J Agric Food Chem       Date:  2009-09-23       Impact factor: 5.279
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