Literature DB >> 939046

Routine assay for the detection of immune complexes of known immunoglobulin class using solid phase C1q.

F C Hay, L J Nineham, I M Roitt.   

Abstract

A new, sensitive and quantitative technique for the routine estimation of immune complexes has been devised. The assay involved the binding of immune complexes to Clq linked to the surface of plastic tubes; the amount of immune complex bound is then determined by adding radiolabelled anti-human IgG. Immune complexes were detected in twelve out of thirty-one patients with systemic lupus erythematosus. The test should prove useful in the diagnosis of immune complex diseases and will be valuable in the evaluation of disease activity.

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Year:  1976        PMID： 939046      PMCID： PMC1538525     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  20 in total

1.  Gamma globulin complexes in rheumatoid arthritis and certain other conditions.

Authors:  H G KUNKEL; H J MULLER-EBERHARD; H H FUDENBERG; T B TOMASI
Journal:  J Clin Invest       Date:  1961-01       Impact factor: 14.808

2.  Preparation of iodine-131 labelled human growth hormone of high specific activity.

Authors:  W M HUNTER; F C GREENWOOD
Journal:  Nature       Date:  1962-05-05       Impact factor: 49.962

3.  Detection and radioassay of soluble circulating immune complexes using guinea pig peritoneal exudate cells.

Authors:  I I Onyewotu; E J Holborow; G D Johnson
Journal:  Nature       Date:  1974-03-08       Impact factor: 49.962

4.  Circulating immune complexes in inflammatory bowel disease.

Authors:  D P Jewell; I C MacLennan
Journal:  Clin Exp Immunol       Date:  1973-06       Impact factor: 4.330

5.  Studies into the occurrence of soluble antigen--antibody complexes in disease. I. A biological assay for soluble complexes.

Authors:  R Baumal; I Broder
Journal:  Clin Exp Immunol       Date:  1968-07       Impact factor: 4.330

6.  Deoxyribonucleic acid antibody: a method to detect its primary interaction with deoxyribonucleic acid.

Authors:  R T Wold; F E Young; E M Tan; R S Farr
Journal:  Science       Date:  1968-08-23       Impact factor: 47.728

7.  Cryoglobulinemia--a study of twenty-nine patients. I. IgG and IgM cryoglobulins and factors affecting cryoprecipitability.

Authors:  M Meltzer; E C Franklin
Journal:  Am J Med       Date:  1966-06       Impact factor: 4.965

8.  Gamma globulin complexes in synovial fluids of patients with rheumatoid arthritis. Partial characterization and relationship to lowered complement levels.

Authors:  R J Winchester; V Agnello; H G Kunkel
Journal:  Clin Exp Immunol       Date:  1970-05       Impact factor: 4.330

9.  Precipitin reactions of the C1q component of complement with aggregated gamma-globulin and immune complexes in gel diffusion.

Authors:  V Agnello; R J Winchester; H G Kunkel
Journal:  Immunology       Date:  1970-12       Impact factor: 7.397

10.  Inhibition of IgG complex-induced platelet aggregation by antiglobulin-active cryoglobulin IgM components.

Authors:  O Wager; K Penttinen; J A Räsänen; G Myllylä
Journal:  Clin Exp Immunol       Date:  1973-11       Impact factor: 4.330
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  119 in total

1.  Rat spleen leucocyte (RSL) radioimmunoassay for the detection and quantification of soluble immune complexes.

Authors:  S F Al-Khateeb; T Barkas
Journal:  Clin Exp Immunol       Date:  1978-12       Impact factor: 4.330

Review 2.  Autoantibodies against C1q: view on clinical relevance and pathogenic role.

Authors:  C E Siegert; M D Kazatchkine; A Sjöholm; R Würzner; M Loos; M R Daha
Journal:  Clin Exp Immunol       Date:  1999-04       Impact factor: 4.330

3.  Aberrant secondary antibody responses to sheep erythrocytes in rabbits with experimental syphilis.

Authors:  R E Baughn; D M Musher
Journal:  Infect Immun       Date:  1979-07       Impact factor: 3.441

4.  Regulation of circulating immune complexes by complement receptor type 1 on erythrocytes in chronic viral liver diseases.

Authors:  J Miyaike; Y Iwasaki; A Takahashi; H Shimomura; H Taniguchi; N Koide; K Matsuura; T Ogura; K Tobe; T Tsuji
Journal:  Gut       Date:  2002-10       Impact factor: 23.059

5.  Low-molecular weight C1q-binding immunoglobulin G in patients with systemic lupus erythematosus consists of autoantibodies to the collagen-like region of C1q.

Authors:  S Uwatoko; M Mannik
Journal:  J Clin Invest       Date:  1988-09       Impact factor: 14.808

6.  Circulating immune complexes in various thyroid diseases.

Authors:  D Brohee; G Delespesse; M J Debisschop; M Bonnyns
Journal:  Clin Exp Immunol       Date:  1979-06       Impact factor: 4.330

7.  Circulating immune complexes in normal pregnant women and in some conditions complicating pregnancy.

Authors:  R D'Amelio; P Bilotta; A Pachì; F Aiuti
Journal:  Clin Exp Immunol       Date:  1979-07       Impact factor: 4.330

8.  Intra-articular and circulating immune complexes and antiglobulins (IgG and IgM) in rheumatoid arthritis; correlation with clinical features.

Authors:  F C Hay; L J Nineham; R Perumal; I M Roitt
Journal:  Ann Rheum Dis       Date:  1979-02       Impact factor: 19.103

9.  The significance of antibodies to poly(adenosine diphosphate-ribose) in systemic lupus erythematosus.

Authors:  E E Okolie; S Shall
Journal:  Clin Exp Immunol       Date:  1979-04       Impact factor: 4.330

10.  New method of hepatocyte transplantation and extracorporeal liver support.

Authors:  A A Demetriou; J Whiting; S M Levenson; N R Chowdhury; R Schechner; S Michalski; D Feldman; J R Chowdhury
Journal:  Ann Surg       Date:  1986-09       Impact factor: 12.969
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