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Literature DB >> 9389739

Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha.

V Modur¹, Y Li, G A Zimmerman, S M Prescott, T M McIntyre.

Abstract

Endothelial cells initiate the inflammatory response by recruiting and activating leukocytes. IL-6 is not an agonist for this, but we found soluble IL-6 receptor alpha-subunit (IL-6Ralpha), with their constitutive IL-6 synthesis, stimulated endothelial cells to synthesize E-selectin, intracellular adhesion molecule-1, vascular cellular adhesion molecule-1, IL-6, and IL-8, and to bind neutrophils. Neutrophils express significant amounts of IL-6Ralpha and upon stimulation shed it: this material activates endothelial cells through a newly constituted IL-6 receptor. Retrograde signaling from PMN activated in the extravascular compartment to surrounding endothelial cells will recruit more and a wider variety of leukocytes. The limiting signal is a soluble receptor, not a cytokine.

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Year: 1997 PMID： 9389739 PMCID： PMC508479 DOI： 10.1172/JCI119821

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

38 in total

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4. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.

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Journal: Immunity Date: 1997-03 Impact factor: 31.745

5. Endothelial cell protein S synthesis is upregulated by the complex of IL-6 and soluble IL-6 receptor.

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Authors: P Vollmer; I Walev; S Rose-John; S Bhakdi
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7. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation.

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8. Oxidative stress during platelet-activating factor-induced microvascular dysfunction.

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9. Endothelial cell inflammatory responses to tumor necrosis factor alpha. Ceramide-dependent and -independent mitogen-activated protein kinase cascades.

Authors: V Modur; G A Zimmerman; S M Prescott; T M McIntyre
Journal: J Biol Chem Date: 1996-05-31 Impact factor: 5.157

10. The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.

Authors: M Peters; S Jacobs; M Ehlers; P Vollmer; J Müllberg; E Wolf; G Brem; K H Meyer zum Büschenfelde; S Rose-John
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9. NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats.

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10. Fibroblasts from different sites may promote or inhibit recruitment of flowing lymphocytes by endothelial cells.

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