Literature DB >> 9389650

sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins.

E J Hubbard1, G Wu, J Kitajewski, I Greenwald.   

Abstract

Mutations that influence lin-12 activity in Caenorhabditis elegans may identify conserved factors that regulate the activity of lin-12/Notch proteins. We describe genetic evidence indicating that sel-10 is a negative regulator of lin-12/Notch-mediated signaling in C. elegans. Sequence analysis shows that SEL-10 is a member of the CDC4 family of proteins and has a potential human ortholog. Coimmunoprecipitation data indicate that C. elegans SEL-10 complexes with LIN-12 and with murine Notch4. We propose that SEL-10 promotes the ubiquitin-mediated turnover of LIN-12/Notch proteins, and discuss potential roles for the regulation of lin-12/Notch activity by sel-10 in cell fate decisions and tumorigenesis.

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Year:  1997        PMID： 9389650      PMCID： PMC316751          DOI： 10.1101/gad.11.23.3182

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  56 in total

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Journal:  Genes Dev       Date:  1995-02-01       Impact factor: 11.361

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Journal:  Cell       Date:  1994-10-07       Impact factor: 41.582

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Journal:  Nature       Date:  1994-09-22       Impact factor: 49.962

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Authors:  J Kimble
Journal:  Dev Biol       Date:  1981-10-30       Impact factor: 3.582

6.  The lin-12 locus specifies cell fates in Caenorhabditis elegans.

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Journal:  Cell       Date:  1983-09       Impact factor: 41.582

7.  The sulfur controller-2 negative regulatory gene of Neurospora crassa encodes a protein with beta-transducin repeats.

Authors:  A Kumar; J V Paietta
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-11       Impact factor: 11.205

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Authors:  S Brenner
Journal:  Genetics       Date:  1974-05       Impact factor: 4.562

Review 9.  Recurrent chromosomal translocations and fusion genes in leukemia-lymphoma cell lines.

Authors:  H G Drexler; R A MacLeod; A Borkhardt; J W Janssen
Journal:  Leukemia       Date:  1995-03       Impact factor: 11.528

10.  Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision.

Authors:  H A Wilkinson; K Fitzgerald; I Greenwald
Journal:  Cell       Date:  1994-12-30       Impact factor: 41.582
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  81 in total

1.  Dominant-negative mutation in the beta2 and beta6 proteasome subunit genes affect alternative cell fate decisions in the Drosophila sense organ lineage.

Authors:  F Schweisguth
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

2.  SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation.

Authors:  G Wu; S Lyapina; I Das; J Li; M Gurney; A Pauley; I Chui; R J Deshaies; J Kitajewski
Journal:  Mol Cell Biol       Date:  2001-11       Impact factor: 4.272

3.  Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex.

Authors:  Christy J Fryer; Elise Lamar; Ivana Turbachova; Chris Kintner; Katherine A Jones
Journal:  Genes Dev       Date:  2002-06-01       Impact factor: 11.361

4.  Systematic analysis and nomenclature of mammalian F-box proteins.

Authors:  Jianping Jin; Timothy Cardozo; Ruth C Lovering; Stephen J Elledge; Michele Pagano; J Wade Harper
Journal:  Genes Dev       Date:  2004-11-01       Impact factor: 11.361

5.  The Caenorhabditis elegans CDT-2 ubiquitin ligase is required for attenuation of EGFR signalling in vulva precursor cells.

Authors:  Gino B Poulin; Julie Ahringer
Journal:  BMC Dev Biol       Date:  2010-10-26       Impact factor: 1.978

6.  A genetic screen for neurite outgrowth mutants in Caenorhabditis elegans reveals a new function for the F-box ubiquitin ligase component LIN-23.

Authors:  Nehal Mehta; Paula M Loria; Oliver Hobert
Journal:  Genetics       Date:  2004-03       Impact factor: 4.562

7.  Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin.

Authors:  Stefan Pukatzki; Amy T Ma; Andrew T Revel; Derek Sturtevant; John J Mekalanos
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-14       Impact factor: 11.205

8.  Promotional effect of microRNA-194 on breast cancer cells via targeting F-box/WD repeat-containing protein 7.

Authors:  Yaomin Chen; Haiyan Wei; Yu Liu; Shusen Zheng
Journal:  Oncol Lett       Date:  2018-01-23       Impact factor: 2.967

Review 9.  Understanding the molecular basis of Alzheimer's disease using a Caenorhabditis elegans model system.

Authors:  Collin Y Ewald; Chris Li
Journal:  Brain Struct Funct       Date:  2009-12-11       Impact factor: 3.270

Review 10.  Endocytic regulation of Notch signaling.

Authors:  Mark E Fortini; David Bilder
Journal:  Curr Opin Genet Dev       Date:  2009-05-15       Impact factor: 5.578
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