Literature DB >> 9389330

HLA DRB1-DQA1-DQB1 haplotype diversity in two African populations.

L Schnittger1, J May, C C Loeliger, M Y Gallin, K D Erttmann, U Bienzle, P G Kremsner, C G Meyer.   

Abstract

HLA class II DRB1-DQA1-DQB1 haplotypic polymorphism was determined in 120 Liberian and 230 Gabonese individuals. In our study groups, the number of allelic variants observed for each locus was similar to that found in non-African populations. However, 39 novel haplotypes and several yet unrecognized DRB1-DQA1 and DQA1-DQB1 combinations were identified. The extent of HLA-haplotypic variability in Africans appears to result from the high degree of allele combinations rather than from allelic polymorphism.

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Year:  1997        PMID: 9389330     DOI: 10.1111/j.1399-0039.1997.tb02911.x

Source DB:  PubMed          Journal:  Tissue Antigens        ISSN: 0001-2815


  2 in total

1.  Common and well-documented HLA alleles: 2012 update to the CWD catalogue.

Authors:  S J Mack; P Cano; J A Hollenbach; J He; C K Hurley; D Middleton; M E Moraes; S E Pereira; J H Kempenich; E F Reed; M Setterholm; A G Smith; M G Tilanus; M Torres; M D Varney; C E M Voorter; G F Fischer; K Fleischhauer; D Goodridge; W Klitz; A-M Little; M Maiers; S G E Marsh; C R Müller; H Noreen; E H Rozemuller; A Sanchez-Mazas; D Senitzer; E Trachtenberg; Marcelo Fernandez-Vina
Journal:  Tissue Antigens       Date:  2013-04

2.  Autosomal, mtDNA, and Y-chromosome diversity in Amerinds: pre- and post-Columbian patterns of gene flow in South America.

Authors:  N R Mesa; M C Mondragón; I D Soto; M V Parra; C Duque; D Ortíz-Barrientos; L F García; I D Velez; M L Bravo; J G Múnera; G Bedoya; M C Bortolini; A Ruiz-Linares
Journal:  Am J Hum Genet       Date:  2000-10-13       Impact factor: 11.043

  2 in total

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