Literature DB >> 9389079

OxLDL-induced cytotoxicity and its inhibition by API0134 in cultured porcine aortic endothelial cells.

H Wang1, H Zhao, B Ma.   

Abstract

Protective effects of API0134 on endothelial cells (EC) damaged by oxidatively modified low density lipoprotein (oxLDL) were studied. The results showed that the content of endothelia (ET) and malondialdehyde (MDA) in the media of porcine aortic EC incubated with oxLDL were increased and the cGMP was decreased significantly, and the activity of superoxide dismutase (SOD) was inhibited. The effect of cytotoxicity of oxLDL can be eliminated by API0134. These results suggest that API0134 may protect EC against damages elicited by oxLDL.

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Year:  1996        PMID： 9389079     DOI： 10.1007/bf02888104

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  4 in total

1.  Cu2(+)-mediated oxidation of dialyzed plasma: effects on low and high density lipoproteins and cholesteryl ester transfer protein.

Authors:  Z Zawadzki; R W Milne; Y L Marcel
Journal:  J Lipid Res       Date:  1991-02       Impact factor: 5.922

Review 2.  The pathogenesis of atherosclerosis: a perspective for the 1990s.

Authors:  R Ross
Journal:  Nature       Date:  1993-04-29       Impact factor: 49.962

Review 3.  Intact and altered endothelium in regulation of vasomotion.

Authors:  A Lerman; J C Burnett
Journal:  Circulation       Date:  1992-12       Impact factor: 29.690

4.  Prevention of atherosclerotic arterial stenosis and restenosis after angioplasty with Andrographis paniculata nees and fish oil. Experimental studies of effects and mechanisms.

Authors:  D W Wang; H Y Zhao
Journal:  Chin Med J (Engl)       Date:  1994-06       Impact factor: 2.628
  4 in total

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