Motoneuron differentiation, survival and synaptogenesis.

The motoneuron is the central neuron whose development is best understood. Recent research has provided much new information about the molecules involved in aspects of motoneuron development first outlined by classic embryology studies. Over the past year, progress has been particularly apparent in the following areas: motoneuron induction and control of motoneuron identity; factors that guide motor axon outgrowth; neurotrophic factors for motoneurons; and early steps in the formation of the neuromuscular junction.