| Literature DB >> 9388128 |
M F Muldoon1, J D Flory, A Marsland, S B Manuck, T L Whiteside, B Rabin.
Abstract
Laboratory investigations have demonstrated that blockade of HMG-CoA reductase in vitro reduces lymphocyte proliferation in response to mitogens as well as other facets of the immune system, such as natural killer cell cytotoxicity. However, in this randomized and double-blind clinical investigation, treatment with 20-mg lovastatin for 6 months did not significantly alter several enumerative and functional characteristics of circulating immune cells.Entities:
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Year: 1997 PMID： 9388128 DOI： 10.1016/s0002-9149(97)00695-4
Source DB: PubMed Journal: Am J Cardiol ISSN： 0002-9149 Impact factor: 2.778