Literature DB >> 9386352

The enhancer shift: a model to explain the developmental control of IgH gene expression in B-lineage cells.

V Arulampalam1, L Eckhardt, S Pettersson.   

Abstract

The roles attributed to the E mu enhancer and the downstream 3' regions acting as locus control regions (LCRs) have allowed comparisons to be drawn between regulation of the IgH locus in early and late B-cell development and other systems governed by LCR activity. Here, the importance of the IgH 3'LCR and its putative functional role in the control of IgH gene expression is evaluated and compared with the 5'LCR regulatory region of the human beta-globin locus.

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Year:  1997        PMID： 9386352     DOI： 10.1016/s0167-5699(97)01154-7

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  5 in total

1.  Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system.

Authors:  Stephen Greenbaum; Yuan Zhuang
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-01       Impact factor: 11.205

2.  Corecruitment of the Grg4 repressor by PU.1 is critical for Pax5-mediated repression of B-cell-specific genes.

Authors:  Ylva Linderson; Dirk Eberhard; Stephen Malin; Annica Johansson; Meinrad Busslinger; Sven Pettersson
Journal:  EMBO Rep       Date:  2004-02-20       Impact factor: 8.807

3.  Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer.

Authors:  A Muto; H Hoshino; L Madisen; N Yanai; M Obinata; H Karasuyama; N Hayashi; H Nakauchi; M Yamamoto; M Groudine; K Igarashi
Journal:  EMBO J       Date:  1998-10-01       Impact factor: 11.598

4.  In a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3' regulatory region induces MYC expression at the immature stage of B cell development.

Authors:  Yi Yan; Sung Sup Park; Siegfried Janz; Laurel A Eckhardt
Journal:  Genes Chromosomes Cancer       Date:  2007-10       Impact factor: 5.006

5.  The epigenetic stability of the locus control region-deficient IgH locus in mouse hybridoma cells is a clonally varying, heritable feature.

Authors:  Diana Ronai; Maribel Berru; Marc J Shulman
Journal:  Genetics       Date:  2004-05       Impact factor: 4.562
  5 in total

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