Literature DB >> 938613

Ovarian failure following abdominal irradiation in childhood.

S M Shalet, C G Beardwell, P H Jones, D Pearson, D H Orrell.   

Abstract

Ovarian function was studied in 18 female patients treated for abdominal tumours during childhood. All received abdominal radiotherapy as part of their treatment and were studied between 1 and 26 years after irradiation. The serum gonadotrophins and oestradiol levels were consistent with ovarian failure in each case but there was a disproportionate elevation in serum follicle stimulating hormone (FSH) when compared to serum luteinizing hormone (LH) in 16. In 2 patients, the radiotherapeutic field extended downwards only as far as the sacral promontory. However, these 2 girls show similar evidence of ovarian failure to that in the other 16.

Entities:  

Keywords:  Biology; Endocrine System; Estradiol--analysis; Estrogens; Follicle Stimulating Hormone--analysis; Genitalia; Genitalia, Female; Gonadotropins; Gonadotropins, Pituitary; Hematological Effects; Hemic System; Hormones; Luteinizing Hormone--analysis; Ovary; Physiology; Urogenital System

Mesh：

Substances：

Year:  1976        PMID： 938613      PMCID： PMC2025110          DOI： 10.1038/bjc.1976.103

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  12 in total

1.  TUMOURS OF THE KIDNEYS AND SUPRARENALS. V. WILM'S TUMOURS--A REVIEW OF 96 CONSECUTIVE CASES.

Authors:  D PEARSON; W B DUNCAN; R C POINTON
Journal:  Br J Radiol       Date:  1964-02       Impact factor: 3.039

2.  Preservation of ovarian function in patients requiring radiotherapy for para-aortic and pelvic Hodgkin's disease.

Authors:  J W Baker; R L Morgan; M J Peckham; D W Smithers
Journal:  Lancet       Date:  1972-06-17       Impact factor: 79.321

3.  Cyclophosphamide and reproductive function.

Authors:  R Kumar; J D Biggart; J McEvoy; M G McGeown
Journal:  Lancet       Date:  1972-06-03       Impact factor: 79.321

4.  Multiple late complications of therapy with cyclophosphamide, including ovarian destruction.

Authors:  J J Miller; G F Williams; J C Leissring
Journal:  Am J Med       Date:  1971-04       Impact factor: 4.965

5.  Hormonal characteristics of the human menstrual cycle throughout reproductive life.

Authors:  B M Sherman; S G Korenman
Journal:  J Clin Invest       Date:  1975-04       Impact factor: 14.808

6.  A diphasic pattern of gonadotropin secretion in patients with the syndrome of gonadal dysgenesis.

Authors:  F A Conte; M M Grumbach; S L Kaplan
Journal:  J Clin Endocrinol Metab       Date:  1975-04       Impact factor: 5.958

7.  Correlation of serum follicular stimulating hormone (FSH) and luteinizing hormone (LH) as measured by radioimmunoassay in disorders of sexual development.

Authors:  R Penny; H J Guyda; A Baghdassarian; A J Johanson; R M Blizzard
Journal:  J Clin Invest       Date:  1970-10       Impact factor: 14.808

8.  Natural history and treatment of Wilms's tumour: an analysis of 335 cases occurring in England and Wales 1962-6.

Authors:  E M Ledlie; L S Mynors; G J Draper; P D Gorbach
Journal:  Br Med J       Date:  1970-10-24

9.  Effect of synthetic luteinizing hormone-releasing hormone (LH-RH) on the release of gonadotropins in hypophyso-gonadal disorders of children and adolescents. V. Agonadism.

Authors:  J C Job; P E Garnier; J L Chaussain; R Scholler; J E Toublanc; P Canlorbe
Journal:  J Clin Endocrinol Metab       Date:  1974-06       Impact factor: 5.958

10.  Serum oestradiol-17 beta in normal women.

Authors:  P C England; L G Skinner; K M Cottrell; R A Sellwood
Journal:  Br J Cancer       Date:  1974-06       Impact factor: 7.640
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  14 in total

Review 1.  Endocrine consequences of treatment of malignant disease in childhood: a review.

Authors:  S M Shalet; C G Beardwell
Journal:  J R Soc Med       Date:  1979-01       Impact factor: 5.344

2.  Treatment of childhood cancer: effects on the gonads.

Authors: 
Journal:  Br Med J       Date:  1978-09-16

Review 3.  [Radiation reactions in the gonads: importance in patient counseling].

Authors:  T Herrmann
Journal:  Strahlenther Onkol       Date:  1997-10       Impact factor: 3.621

4.  Growth and endocrine function after treatment for medulloblastoma.

Authors:  I H Brown; T J Lee; O B Eden; J A Bullimore; D C Savage
Journal:  Arch Dis Child       Date:  1983-09       Impact factor: 3.791

5.  Fertility of female survivors of childhood cancer: a report from the childhood cancer survivor study.

Authors:  Daniel M Green; Toana Kawashima; Marilyn Stovall; Wendy Leisenring; Charles A Sklar; Ann C Mertens; Sarah S Donaldson; Julianne Byrne; Leslie L Robison
Journal:  J Clin Oncol       Date:  2009-04-13       Impact factor: 44.544

6.  Gonadal dysfunction after treatment of intracranial tumours.

Authors:  E A Livesey; C G Brook
Journal:  Arch Dis Child       Date:  1988-05       Impact factor: 3.791

7.  Gonadal function in patients treated for Hodgkin's disease in childhood.

Authors:  Lorna Zadravec Zaletel; Nevenka Bratanic; Berta Jereb
Journal:  Radiol Oncol       Date:  2010-09-09       Impact factor: 2.991

Review 8.  Wilms tumour: diagnosis and treatment.

Authors:  M J Coppes; J E Wolff; M L Ritchey
Journal:  Paediatr Drugs       Date:  1999 Oct-Dec       Impact factor: 3.930

9.  Influence of irradiation and chemotherapy on the ovaries of children with abdominal tumours.

Authors:  R Himelstein-Braw; H Peters; M Faber
Journal:  Br J Cancer       Date:  1977-08       Impact factor: 7.640

10.  Effect of radiation on the human reproductive system.

Authors:  A L Ogilvy-Stuart; S M Shalet
Journal:  Environ Health Perspect       Date:  1993-07       Impact factor: 9.031
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