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Literature DB >> 9385841

How does DNA methylation repress transcription?

Abstract

DNA methylation has an essential regulatory function in mammalian development, serving to repress nontranscribed genes stably in differentiated adult somatic cells. Recent data implicate transcriptional repressors specific for methylated DNA and chromatin assembly in this global control of gene activity. The assembly of specialized nucleosomal structures on methylated DNA helps to explain the capacity of methylated DNA segments to silence transcription more effectively than conventional chromatin. Specialized nucleosomes also provide a potential molecular mechanism for the stable propagation of DNA methylation-dependent transcriptional silencing through cell division.

Entities: Species

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Substances：
Chromatin

Year: 1997 PMID： 9385841 DOI： 10.1016/s0168-9525(97)01268-7

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

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Cited

142 in total

1. M.(phi)BssHII, a novel cytosine-C5-DNA-methyltransferase with target-recognizing domains at separated locations of the enzyme.

Authors: S Sethmann; P Ceglowski; J Willert; R Iwanicka-Nowicka; T A Trautner; J Walter
Journal: EMBO J Date: 1999-06-15 Impact factor: 11.598

2. In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b.

Authors: C L Hsieh
Journal: Mol Cell Biol Date: 1999-12 Impact factor: 4.272

3. RNA-DNA interactions and DNA methylation in post-transcriptional gene silencing.

Authors: L Jones; A J Hamilton; O Voinnet; C L Thomas; A J Maule; D C Baulcombe
Journal: Plant Cell Date: 1999-12 Impact factor: 11.277

4. MeCP2 driven transcriptional repression in vitro: selectivity for methylated DNA, action at a distance and contacts with the basal transcription machinery.

Authors: N K Kaludov; A P Wolffe
Journal: Nucleic Acids Res Date: 2000-05-01 Impact factor: 16.971

9. The involvement of photoregulated DNA methylation into a choice between sexual and asexual developmental pathways in Neurospora crassa.

Authors: M S Kritsky; S Filippovich; T P Afanasieva; G P Bachurina; V E Russo
Journal: Dokl Biochem Biophys Date: 2001 May-Jun Impact factor: 0.788

10. Methylation of the Opaque2 box in zein genes is parent-dependent and affects O2 DNA binding activity in vitro.

Authors: M Sturaro; A Viotti
Journal: Plant Mol Biol Date: 2001-07 Impact factor: 4.076

How does DNA methylation repress transcription?

1. M.(phi)BssHII, a novel cytosine-C5-DNA-methyltransferase with target-recognizing domains at separated locations of the enzyme.

2. In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b.

3. RNA-DNA interactions and DNA methylation in post-transcriptional gene silencing.

4. MeCP2 driven transcriptional repression in vitro: selectivity for methylated DNA, action at a distance and contacts with the basal transcription machinery.

Review 5. Survey and summary: transcription by RNA polymerases I and III.

Review 6. Molecular regulation of cytokine gene expression during the immune response.

7. Differential regulation of the human nidogen gene promoter region by a novel cell-type-specific silencer element.

8. K562 cells implicate increased chromatin accessibility in Alu transcriptional activation.

9. The involvement of photoregulated DNA methylation into a choice between sexual and asexual developmental pathways in Neurospora crassa.

10. Methylation of the Opaque2 box in zein genes is parent-dependent and affects O2 DNA binding activity in vitro.