Literature DB >> 938491

The effect of some analogues of disulfiram on the aldehyde dehydrogenases of sheep liver.

T M Kitson.   

Abstract

The effect of some close structural analogues of disulfiram on the activity of the cytoplasmic and mitochondrial aldehyde dehydrogenases of sheep liver was studied. Several thiuram disulphides are equally potent inhibitors of the cytoplasmic enzyme, but in all cases the mitochondrial enzyme is much less strongly affected. Tetramethylthiuram monosulphide decreases the activity of the cytoplasmic enzyme in a process apparently involving a covalent interaction.

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Year:  1976        PMID： 938491      PMCID： PMC1172852          DOI： 10.1042/bj1550445

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  9 in total

1.  INHIBITION OF DOPAMINE-BETA-HYDROXYLASE BY DISULFIRAM.

Authors:  M GOLDSTEIN; B ANAGNOSTE; E LAUBER; M R MCKEREGHAM
Journal:  Life Sci (1962)       Date:  1964-07

2.  The antabuse effect of some compounds related to antabuse and cyanamide.

Authors:  J HALD; E JACOBSEN; V LARSEN
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1952

3.  The effect of disulfiram on the aldehyde dehydrogenases of sheep liver.

Authors:  T M Kitson
Journal:  Biochem J       Date:  1975-11       Impact factor: 3.857

4.  Intracellular localisation and properties of aldehyde dehydrogenases from sheep liver.

Authors:  K E Crow; T M Kitson; A K MacGibbon; R D Batt
Journal:  Biochim Biophys Acta       Date:  1974-05-20

5.  Mechanism of the inhibition of aldehyde dehydrogenase in vivo by disulfiram and diethyldithiocarbamate.

Authors:  R A Deitrich; V G Erwin
Journal:  Mol Pharmacol       Date:  1971-05       Impact factor: 4.436

6.  A sensitive radioassay for sulfhydryl groups with tetraethylthiuram disulfide.

Authors:  A H Neims; D S Coffey; L Hellerman
Journal:  J Biol Chem       Date:  1966-07-10       Impact factor: 5.157

7.  Interaction between tetraethylthiuram disulfide and the sulfhydryl groups of D-amino acid oxidase and of hemoglobin.

Authors:  A H Neims; D S Coffey; L Hellerman
Journal:  J Biol Chem       Date:  1966-12-25       Impact factor: 5.157

8.  Diphosphopyridine nucleotide-linked aldehyde dehydrogenase. 3. Sulfhydryl characteristics of the enzyme.

Authors:  R A Deitrich
Journal:  Arch Biochem Biophys       Date:  1967-03       Impact factor: 4.013

9.  Diethyldithiocarbamic acid methyl ester. A metabolite of disulfiram.

Authors:  T Gessner; M Jakubowski
Journal:  Biochem Pharmacol       Date:  1972-01-15       Impact factor: 5.858
  9 in total
  9 in total

1.  2,2'-Dithiodipyridine activates aldehyde dehydrogenase and protects the enzyme against inactivation by disulfiram.

Authors:  T M Kitson
Journal:  Biochem J       Date:  1979-12-01       Impact factor: 3.857

2.  Further studies of the action of disulfiram and 2,2'-dithiodipyridine on the dehydrogenase and esterase activities of sheep liver cytoplasmic aldehyde dehydrogenase.

Authors:  T M Kitson
Journal:  Biochem J       Date:  1982-06-01       Impact factor: 3.857

3.  Studies on the interaction between disulfiram and sheep liver cytoplasmic aldehyde dehydrogenase.

Authors:  T M Kitson
Journal:  Biochem J       Date:  1978-10-01       Impact factor: 3.857

4.  Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer.

Authors:  Ghali Brahemi; Fathima R Kona; Annalisa Fiasella; Daniela Buac; Jitka Soukupová; Andrea Brancale; Angelika M Burger; Andrew D Westwell
Journal:  J Med Chem       Date:  2010-04-08       Impact factor: 7.446

5.  Inhibition of erythrocyte aldehyde dehydrogenase activity and elimination kinetics of diethyldithiocarbamic acid methyl ester and its monothio analogue after administration of single and repeated doses of disulfiram to man.

Authors:  B Johansson; Z Stankiewicz
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

6.  Probing the active site of cytoplasmic aldehyde dehydrogenase with a chromophoric reporter group.

Authors:  T M Kitson; K E Kitson
Journal:  Biochem J       Date:  1994-05-15       Impact factor: 3.857

7.  Effect of some thiocarbamate compounds on aldehyde dehydrogenase and implications for the disulfiram ethanol reaction.

Authors:  T M Kitson
Journal:  Biochem J       Date:  1991-08-15       Impact factor: 3.857

8.  Involvement of a single thiol group in the conversion of the NAD+-dependent activity of rat liver xanthine oxidoreductase to the O2-dependent activity.

Authors:  Z W Kamiński; M M Jezewska
Journal:  Biochem J       Date:  1982-11-01       Impact factor: 3.857

9.  Reaction between sheep liver mitochondrial aldehyde dehydrogenase and various thiol-modifying reagents.

Authors:  K M Loomes; T M Kitson
Journal:  Biochem J       Date:  1989-07-01       Impact factor: 3.857
  9 in total

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