| Literature DB >> 9383519 |
C K Kim1, L E Kalynchuk, T J Kornecook, D G Mumby, N A Dadgar, J P Pinel, J Weinberg.
Abstract
Prenatal ethanol exposure can produce cognitive and behavioral impairments. In the present study, rats from prenatal ethanol (E), pair-fed (PF), and ad libitum-fed control (C) treatment conditions were tested on the object-recognition delayed-nonmatching-to-sample (DNMS) task with nonrecurring items and on the spatial-navigation Morris water maze task. In Experiment 1, there were no significant differences among groups in object-recognition learning and memory, distractibility, or response perseveration on the DNMS task. In Experiment 2, the same rats were tested in the water maze; E rats took significantly longer to learn the task than did the PF or C rats. These data suggest that the mechanisms underlying spatial cognitive abilities are more vulnerable to the teratogenic effects of prenatal ethanol exposure than those underlying object-recognition abilities.Entities:
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Year: 1997 PMID： 9383519 DOI： 10.1037//0735-7044.111.5.985
Source DB: PubMed Journal: Behav Neurosci ISSN： 0735-7044 Impact factor: 1.912