Literature DB >> 9383460

Microtubule dynamics: taking aim at a moving target.

L Wilson1, M A Jordan.   

Abstract

Antitumor drugs of the vinca alkaloid and taxane classes function by suppressing the dynamics of microtubules in spindles, blocking cell division at metaphase. The drugs bind to various sites on the tubulin dimer and at different positions within the microtubule, suggesting that there are many unexplored targets for the design of novel drugs of this type.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 9383460     DOI： 10.1016/1074-5521(95)90119-1

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  41 in total

1.  Altered time course of mRNA expression of alpha tubulin in the central nervous system of hens treated with diisopropyl phosphorofluoridate (DFP).

Authors:  T V Damodaran; A Abdel-Rahman; M B Abou-Donia
Journal:  Neurochem Res       Date:  2001-01       Impact factor: 3.996

Review 2.  Mechanisms of Taxol resistance related to microtubules.

Authors:  George A Orr; Pascal Verdier-Pinard; Hayley McDaid; Susan Band Horwitz
Journal:  Oncogene       Date:  2003-10-20       Impact factor: 9.867

3.  beta-Tubulin C354 mutations that severely decrease microtubule dynamics do not prevent nuclear migration in yeast.

Authors:  Mohan L Gupta; Claudia J Bode; Douglas A Thrower; Chad G Pearson; Kathy A Suprenant; Kerry S Bloom; Richard H Himes
Journal:  Mol Biol Cell       Date:  2002-08       Impact factor: 4.138

4.  Post-translational modifications of tubulin and microtubule stability in adult rat ventricular myocytes and immortalized HL-1 cardiomyocytes.

Authors:  Souad Belmadani; Christian Poüs; Rodolphe Fischmeister; Pierre-François Méry
Journal:  Mol Cell Biochem       Date:  2004-03       Impact factor: 3.396

Review 5.  Antimicrotubular drugs binding to vinca domain of tubulin.

Authors:  Suvroma Gupta; Bhabatarak Bhattacharyya
Journal:  Mol Cell Biochem       Date:  2003-11       Impact factor: 3.396

6.  Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro.

Authors:  R J Vasquez; B Howell; A M Yvon; P Wadsworth; L Cassimeris
Journal:  Mol Biol Cell       Date:  1997-06       Impact factor: 4.138

7.  Induction of paclitaxel resistance by the Kaposi's sarcoma-associated herpesvirus latent protein LANA2.

Authors:  C Muñoz-Fontela; L Marcos-Villar; F Hernandez; P Gallego; E Rodriguez; J Arroyo; S-J Gao; J Avila; C Rivas
Journal:  J Virol       Date:  2007-11-21       Impact factor: 5.103

8.  Relating molecular flexibility to function: a case study of tubulin.

Authors:  Ozlem Keskin; Stewart R Durell; Ivet Bahar; Robert L Jernigan; David G Covell
Journal:  Biophys J       Date:  2002-08       Impact factor: 4.033

9.  Phenethyl isothiocyanate induces cell cycle arrest and reduction of alpha- and beta-tubulin isotypes in human prostate cancer cells.

Authors:  Ping Yin; Tomoya Kawamura; Meilan He; Donkena Krishna Vanaja; Charles Y F Young
Journal:  Cell Biol Int       Date:  2008-10-11       Impact factor: 3.612

10.  Antineoplastic potency of arylchloroethylurea derivatives in murine colon carcinoma.

Authors:  Elisabeth Miot-Noirault; Jean Legault; Florent Cachin; Emmanuelle Mounetou; Françoise Degoul; René C Gaudreault; Nicole Moins; Jean Claude Madelmont
Journal:  Invest New Drugs       Date:  2004-11       Impact factor: 3.850
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.