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Literature DB >> 9383453

New insights into proteasome function: from archaebacteria to drug development.

Abstract

The proteasome is not simply a 'garbage disposal unit' but also has functions in the control of the cell cycle and immune responses. The structure of an archaebacterial proteasome has recently been determined to high resolution, and provides insight into the unusual mechanism of proteolytic cleavage by the proteasome.

Mesh：

Substances：
Ubiquitins
Endopeptidases

Year: 1995 PMID： 9383453 DOI： 10.1016/1074-5521(95)90182-5

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

Keyword Cloud
Cited

32 in total

1. Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles.

Authors: N E Tawa; R Odessey; A L Goldberg
Journal: J Clin Invest Date: 1997-07-01 Impact factor: 14.808

2. Role of the proteasome and NF-kappaB in streptococcal cell wall-induced polyarthritis.

Authors: V J Palombella; E M Conner; J W Fuseler; A Destree; J M Davis; F S Laroux; R E Wolf; J Huang; S Brand; P J Elliott; D Lazarus; T McCormack; L Parent; R Stein; J Adams; M B Grisham
Journal: Proc Natl Acad Sci U S A Date: 1998-12-22 Impact factor: 11.205

3. Proteasomes play an essential role in thymocyte apoptosis.

Authors: L M Grimm; A L Goldberg; G G Poirier; L M Schwartz; B A Osborne
Journal: EMBO J Date: 1996-08-01 Impact factor: 11.598

4. Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation.

Authors: M Krüger; C Beger; P J Welch; J R Barber; M P Manns; F Wong-Staal
Journal: Mol Cell Biol Date: 2001-12 Impact factor: 4.272

5. Fundamental reaction pathway for peptide metabolism by proteasome: insights from first-principles quantum mechanical/molecular mechanical free energy calculations.

Authors: Donghui Wei; Lei Fang; Mingsheng Tang; Chang-Guo Zhan
Journal: J Phys Chem B Date: 2013-10-10 Impact factor: 2.991

6. The clinically approved proteasome inhibitor PS-341 efficiently blocks influenza A virus and vesicular stomatitis virus propagation by establishing an antiviral state.

Authors: Sabine Eva Dudek; Christina Luig; Eva-Katharina Pauli; Ulrich Schubert; Stephan Ludwig
Journal: J Virol Date: 2010-06-30 Impact factor: 5.103

New insights into proteasome function: from archaebacteria to drug development.

1. Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles.

2. Role of the proteasome and NF-kappaB in streptococcal cell wall-induced polyarthritis.

3. Proteasomes play an essential role in thymocyte apoptosis.

4. Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation.

5. Fundamental reaction pathway for peptide metabolism by proteasome: insights from first-principles quantum mechanical/molecular mechanical free energy calculations.

6. The clinically approved proteasome inhibitor PS-341 efficiently blocks influenza A virus and vesicular stomatitis virus propagation by establishing an antiviral state.

7. NOB1 is essential for the survival of RKO colorectal cancer cells.

8. Defining the Critical Region for Intellectual Disability and Brain Malformations in 6q27 Microdeletions.

Review 9. Proteasome inhibition: a new anti-inflammatory strategy.

10. Peptide and Peptide-Like Modulators of 20S Proteasome Enzymatic Activity in Cancer Cells.