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Literature DB >> 9383382

Proximity versus allostery: the role of regulated protein dimerization in biology.

D J Austin¹, G R Crabtree, S L Schreiber.

Abstract

Regulated dimerization of proteins is increasingly understood to be important in many cellular processes, including signaling, transciption and protein degradation. Organic molecules that induce dimerization may offer as much potential to regulate biological processes as those that allosterically induce conformational change.

Mesh：

Substances：
Proteins

Year: 1994 PMID： 9383382 DOI： 10.1016/1074-5521(94)90002-7

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

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Cited

16 in total

1. Minimization of a protein-DNA dimerizer.

Authors: Ryan L Stafford; Hans-Dieter Arndt; Mary L Brezinski; Aseem Z Ansari; Peter B Dervan
Journal: J Am Chem Soc Date: 2007-02-10 Impact factor: 15.419

2. Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins.

Authors: P J Belshaw; S N Ho; G R Crabtree; S L Schreiber
Journal: Proc Natl Acad Sci U S A Date: 1996-05-14 Impact factor: 11.205

3. A versatile synthetic dimerizer for the regulation of protein-protein interactions.

Authors: J F Amara; T Clackson; V M Rivera; T Guo; T Keenan; S Natesan; R Pollock; W Yang; N L Courage; D A Holt; M Gilman
Journal: Proc Natl Acad Sci U S A Date: 1997-09-30 Impact factor: 11.205

4. Proteasome inhibition induces nuclear translocation and transcriptional activation of the dioxin receptor in mouse embryo primary fibroblasts in the absence of xenobiotics.

Authors: B Santiago-Josefat; E Pozo-Guisado; S Mulero-Navarro; P M Fernandez-Salguero
Journal: Mol Cell Biol Date: 2001-03 Impact factor: 4.272

5. Dimeric switch of Hakai-truncated monomers during substrate recognition: insights from solution studies and NMR structure.

Authors: Manjeet Mukherjee; Fan Jing-Song; Sarath Ramachandran; Graeme R Guy; J Sivaraman
Journal: J Biol Chem Date: 2014-07-29 Impact factor: 5.157

Proximity versus allostery: the role of regulated protein dimerization in biology.

1. Minimization of a protein-DNA dimerizer.

2. Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins.

3. A versatile synthetic dimerizer for the regulation of protein-protein interactions.

4. Proteasome inhibition induces nuclear translocation and transcriptional activation of the dioxin receptor in mouse embryo primary fibroblasts in the absence of xenobiotics.

5. Dimeric switch of Hakai-truncated monomers during substrate recognition: insights from solution studies and NMR structure.

6. Characterization of the rapamycin-inducible EBV LMP1 activation system.

7. Engineering the ABA plant stress pathway for regulation of induced proximity.

Review 8. Unifying principles of bifunctional, proximity-inducing small molecules.

9. Switchable elastin-like polypeptides that respond to chemical inducers of dimerization.

10. Composite RNA aptamers as functional mimics of proteins.