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Literature DB >> 9383287

Mapping of new recessive cataract gene (lr2) in the mouse.

C W Song¹, M Okumoto, N Mori, J S Kim, S S Han, K Esaki.

Abstract

A new strain of mice with cataracts was developed in BALB/cHeA and STS/A recombinant inbred strain, CXS4 (D). In this study the mapping of spontaneous autosomal recessive cataract mutation is described. This mutation was characterized by ruptures of the lens nucleus, vitreous chamber through the posterior capsule, and the vacuolization of the lens. For the linkage analysis, we produced two kinds of backcross progenies, (BALB/cHeA x D)F1 and (STS/A x D)F1 females crossed to D male mice. The gene (lr2, lens rupture2) was mapped to the central part of Chromosome(Chr) 14, 0.7 +/- 0.7 cM from the micosatellite marker D14Mit28.

Entities: Disease Gene Species

Mesh：

Year: 1997 PMID： 9383287 DOI： 10.1007/s003359900613

Source DB: PubMed Journal: Mamm Genome ISSN： 0938-8990 Impact factor: 2.957

20 in total

1. A genetic map of the mouse suitable for typing intraspecific crosses.

Authors: W Dietrich; H Katz; S E Lincoln; H S Shin; J Friedman; N C Dracopoli; E S Lander
Journal: Genetics Date: 1992-06 Impact factor: 4.562

2. Mapping of rupture of lens cataract (rlc) on mouse chromosome 14.

Authors: Y Matsushima; T Kamoto; F Iida; P Abujiang; Y Honda; H Hiai
Journal: Genomics Date: 1996-09-15 Impact factor: 5.736

3. Phenotypic characterization and genetic analysis of twenty dominant cataract mutations detected in offspring of irradiated male mice.

Authors: J Kratochvilova; J Favor
Journal: Genet Res Date: 1988-10 Impact factor: 1.588

4. Genetic dissection of susceptibility to radiation-induced apoptosis of thymocytes and mapping of Rapop1, a novel susceptibility gene.

Authors: N Mori; M Okumoto; M A van der Valk; S Imai; S Haga; K Esaki; A A Hart; P Demant
Journal: Genomics Date: 1995-02-10 Impact factor: 5.736

Mapping of new recessive cataract gene (lr2) in the mouse.

1. A genetic map of the mouse suitable for typing intraspecific crosses.

2. Mapping of rupture of lens cataract (rlc) on mouse chromosome 14.

3. Phenotypic characterization and genetic analysis of twenty dominant cataract mutations detected in offspring of irradiated male mice.

4. Genetic dissection of susceptibility to radiation-induced apoptosis of thymocytes and mapping of Rapop1, a novel susceptibility gene.

5. A series of recombinant inbred strains between the BALB/cHeA and STS/A mouse strains.

6. Rupture of lens cataract: a novel hereditary recessive cataract model in the mouse.

7. Distribution of genes for gap junction membrane channel proteins on human and mouse chromosomes.

8. Cataract in senescence accelerated mouse (SAM). 2. Development of a new strain of mouse with late-appearing cataract.

Review 9. Autosomal dominant mouse cataract (Lop-10). Consistent differences of expression in heterozygotes.

10. Further experience of the mouse dominant cataract mutation test from an experiment with ethylnitrosourea.

1. A progressive autosomal recessive cataract locus maps to chromosome 9q13-q22.