Literature DB >> 9383019

Diffuse thalamic degeneration in fatal familial insomnia. A morphometric study.

G Macchi1, G Rossi, A L Abbamondi, G Giaccone, D Mancia, F Tagliavini, O Bugiani.   

Abstract

A morphometric investigation disclosed most thalamic nuclei severely degenerated in two patients with fatal familial insomnia. Associative and motor nuclei lost 90% neurons, and limbic-paralimbic, intralaminar and reticular nuclei lost 60%. These findings point to the disorganization of most thalamic circuits as a condition necessary for the sleep-wake rhythm being affected.

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Year:  1997        PMID： 9383019     DOI： 10.1016/s0006-8993(97)00902-5

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  6 in total

1.  Thalamo-striatal diffusion reductions precede disease onset in prion mutation carriers.

Authors:  Hedok Lee; Hanna Rosenmann; Joab Chapman; Peter B Kingsley; Chen Hoffmann; Oren S Cohen; Esther Kahana; Amos D Korczyn; Isak Prohovnik
Journal:  Brain       Date:  2009-03-24       Impact factor: 13.501

2.  Mediodorsal thalamus lesion increases paradoxical sleep in rats.

Authors:  S N Sriji; Nasreen Akhtar; Hruda Nanda Mallick
Journal:  Sleep Sci       Date:  2021 Jan-Mar

3.  Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease.

Authors:  Ihssane Bouybayoune; Susanna Mantovani; Federico Del Gallo; Ilaria Bertani; Elena Restelli; Liliana Comerio; Laura Tapella; Francesca Baracchi; Natalia Fernández-Borges; Michela Mangieri; Cinzia Bisighini; Galina V Beznoussenko; Alessandra Paladini; Claudia Balducci; Edoardo Micotti; Gianluigi Forloni; Joaquín Castilla; Fabio Fiordaliso; Fabrizio Tagliavini; Luca Imeri; Roberto Chiesa
Journal:  PLoS Pathog       Date:  2015-04-16       Impact factor: 6.823

4.  Clinical Features and Sleep Analysis of Chinese Patients with Fatal Familial Insomnia.

Authors:  Liyong Wu; Hui Lu; Xianling Wang; Jia Liu; Chaoyang Huang; Jing Ye; Cuijiang Li; Jun Lu; Yuping Wang; Jianping Jia; Shuqin Zhan
Journal:  Sci Rep       Date:  2017-06-15       Impact factor: 4.379

5.  Clinical features and genetic characteristics of two Chinese pedigrees with fatal family insomnia.

Authors:  Runcheng He; Yacen Hu; Lingyan Yao; Yun Tian; Yafang Zhou; Fang Yi; Lin Zhou; Hongwei Xu; Qiying Sun
Journal:  Prion       Date:  2019-01       Impact factor: 3.931

6.  Clinical profile of fatal familial insomnia: phenotypic variation in 129 polymorphisms and geographical regions.

Authors:  Jing Zhang; Min Chu; ZiChen Tian; KeXin Xie; Yue Cui; Li Liu; JiaLi Meng; HaiHan Yan; Yang-Mingyue Ji; Zhuyi Jiang; Tian-Xinyu Xia; Dongxin Wang; Xin Wang; Ye Zhao; Hong Ye; Junjie Li; Lin Wang; Liyong Wu
Journal:  J Neurol Neurosurg Psychiatry       Date:  2021-10-19       Impact factor: 10.154
  6 in total

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