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Literature DB >> 9382085

The promise and reality of cancer gene therapy.

S J Hall¹, S H Chen, S L Woo.

Abstract

Entities: Disease

Mesh：

Year: 1997 PMID： 9382085 PMCID： PMC1716009 DOI： 10.1086/514898

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

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56 in total

1. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents.

Authors: C Heise; A Sampson-Johannes; A Williams; F McCormick; D D Von Hoff; D H Kirn
Journal: Nat Med Date: 1997-06 Impact factor: 53.440

2. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

Authors: F L Moolten
Journal: Cancer Res Date: 1986-10 Impact factor: 12.701

3. Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity.

Authors: B Gansbacher; R Bannerji; B Daniels; K Zier; K Cronin; E Gilboa
Journal: Cancer Res Date: 1990-12-15 Impact factor: 12.701

4. Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4.

Authors: L Chen; S Ashe; W A Brady; I Hellström; K E Hellström; J A Ledbetter; P McGowan; P S Linsley
Journal: Cell Date: 1992-12-24 Impact factor: 41.582

5. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

Authors: G Dranoff; E Jaffee; A Lazenby; P Golumbek; H Levitsky; K Brose; V Jackson; H Hamada; D Pardoll; R C Mulligan
Journal: Proc Natl Acad Sci U S A Date: 1993-04-15 Impact factor: 11.205

The promise and reality of cancer gene therapy.

1. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents.

2. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

3. Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity.

4. Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4.

5. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

6. Antimetastatic vaccination of tumor-bearing mice with two types of IFN-gamma gene-inserted tumor cells.

7. Anti-metastatic vaccination of tumor-bearing mice with IL-2-gene-inserted tumor cells.

8. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors.

9. Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells.

10. Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.