Literature DB >> 9380736

Reduced stress defense in heme oxygenase 1-deficient cells.

K D Poss1, S Tonegawa.   

Abstract

Stressed mammalian cells up-regulate heme oxygenase 1 (Hmox1; EC 1.14.99.3), which catabolizes heme to biliverdin, carbon monoxide, and free iron. To assess the potential role of Hmox1 in cellular antioxidant defense, we analyzed the responses of cells from mice lacking functional Hmox1 to oxidative challenges. Cultured Hmox1(-/-) embryonic fibroblasts demonstrated high oxygen free radical production when exposed to hemin, hydrogen peroxide, paraquat, or cadmium chloride, and they were hypersensitive to cytotoxicity caused by hemin and hydrogen peroxide. Furthermore, young adult Hmox1(-/-) mice were vulnerable to mortality and hepatic necrosis when challenged with endotoxin. Our in vitro and in vivo results provide genetic evidence that up-regulation of Hmox1 serves as an adaptive mechanism to protect cells from oxidative damage during stress.

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Year:  1997        PMID： 9380736      PMCID： PMC23533          DOI： 10.1073/pnas.94.20.10925

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  37 in total

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  343 in total

1.  Heme oxygenase-1 in tissue pathology: the Yin and Yang.

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Review 3.  Self-cytoprotection against stress: feedback regulation of heme-dependent metabolism.

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Journal:  Neurotoxicology       Date:  2011-09-25       Impact factor: 4.294

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Review 9.  Carbon Monoxide and the brain: time to rethink the dogma.

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10.  Heme oxygenase-1 promotes migration and β-epithelial Na+ channel expression in cytotrophoblasts and ischemic placentas.

Authors:  Junie P Warrington; Kayla Coleman; Courtney Skaggs; Peter A Hosick; Eric M George; David E Stec; Michael J Ryan; Joey P Granger; Heather A Drummond
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2014-02-19       Impact factor: 3.619
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