Literature DB >> 9379078

Mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Its binding motif for alpha 4 beta 7 and role in experimental colitis.

S Fong1, S Jones, M E Renz, H H Chiu, A M Ryan, L G Presta, D Jackson.   

Abstract

The integrin alpha 4 beta 7 and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) are molecules involved in the normal recirculation of lymphocytes between the blood and the gastrointestinal tract. These molecules may play a complementary and significant role in animal models of colitis. We have investigated the structural interaction between alpha 4 beta 7 and MAdCAM-1. Site-directed mutagenesis studies of the MAdCAM-1 molecule has led to the identification of the amino acid residue (LDT) in the loop between beta strands C and D of the Ig-superfamily-like folds being involved in the adhesive and cell activation functions of MAdCAM-1 with alpha 4 beta 7.

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Year:  1997        PMID： 9379078     DOI： 10.1007/BF02786396

Source DB:  PubMed          Journal:  Immunol Res        ISSN： 0257-277X            Impact factor:   2.829


  89 in total

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Journal:  Nature       Date:  1993-12-16       Impact factor: 49.962

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Journal:  Gastroenterology       Date:  1996-11       Impact factor: 22.682

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Journal:  J Immunol       Date:  1996-05-01       Impact factor: 5.422

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Journal:  Eur J Immunol       Date:  1993-07       Impact factor: 5.532

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Journal:  J Biol Chem       Date:  1992-04-25       Impact factor: 5.157

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Journal:  EMBO J       Date:  1989-06       Impact factor: 11.598

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Journal:  J Exp Med       Date:  1992-04-01       Impact factor: 14.307
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  16 in total

1.  FRET detection of cellular alpha4-integrin conformational activation.

Authors:  Alexandre Chigaev; Tione Buranda; Denise C Dwyer; Eric R Prossnitz; Larry A Sklar
Journal:  Biophys J       Date:  2003-12       Impact factor: 4.033

2.  In vivo demonstration of T lymphocyte migration and amelioration of ileitis in intestinal mucosa of SAMP1/Yit mice by the inhibition of MAdCAM-1.

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Journal:  Clin Exp Immunol       Date:  2005-04       Impact factor: 4.330

Review 3.  Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4.

Authors:  M P Rettig; G Ansstas; J F DiPersio
Journal:  Leukemia       Date:  2011-09-02       Impact factor: 11.528

4.  Exosomal regulation of lymphocyte homing to the gut.

Authors:  Eun Jeong Park; Onmanee Prajuabjinda; Zay Yar Soe; Samuel Darkwah; Michael G Appiah; Eiji Kawamoto; Fumiyasu Momose; Hiroshi Shiku; Motomu Shimaoka
Journal:  Blood Adv       Date:  2019-01-08

5.  Identification of an adhesion molecule expressed on adult T cell leukemia cells derived from a patient with gastrointestinal involvement: implication for a possible role of integrin beta 7 in leukemic cell infiltration into intestinal mucosa.

Authors:  H Chen; T Hori; M Maeda; T Uchiyama
Journal:  J Clin Immunol       Date:  1999-05       Impact factor: 8.317

6.  Blocking MAdCAM-1 in vivo reduces leukocyte extravasation and reverses chronic inflammation in experimental colitis.

Authors:  Stefan Farkas; Matthias Hornung; Christine Sattler; Karoline Edtinger; Markus Steinbauer; Matthias Anthuber; Hans J Schlitt; Hans Herfarth; Edward K Geissler
Journal:  Int J Colorectal Dis       Date:  2005-04-23       Impact factor: 2.571

7.  Phylogenetic analysis and homology modelling of Paracentrotus lividus nectin.

Authors:  Caterina Costa; Carmela Cavalcante; Francesca Zito; Yukio Yokota; Valeria Matranga
Journal:  Mol Divers       Date:  2009-11-12       Impact factor: 2.943

8.  Indium-labelled human gut-derived T cells from healthy subjects with strong in vitro adhesion to MAdCAM-1 show no detectable homing to the gut in vivo.

Authors:  J Kelsen; J Agnholt; L Falborg; J T Nielsen; J L Rømer; H J Hoffmann; J F Dahlerup
Journal:  Clin Exp Immunol       Date:  2004-10       Impact factor: 4.330

9.  Higher plasma fractalkine is associated with better 6-month outcome from ischemic stroke.

Authors:  Megan M Donohue; Kevin Cain; Dannielle Zierath; Dean Shibata; Patricia M Tanzi; Kyra J Becker
Journal:  Stroke       Date:  2012-07-12       Impact factor: 7.914

10.  Blocking lymphotoxin-beta receptor activation diminishes inflammation via reduced mucosal addressin cell adhesion molecule-1 (MAdCAM-1) expression and leucocyte margination in chronic DSS-induced colitis.

Authors:  P Stopfer; F Obermeier; N Dunger; W Falk; S Farkas; M Janotta; A Möller; D N Männel; T Hehlgans
Journal:  Clin Exp Immunol       Date:  2004-04       Impact factor: 4.330
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