Expression of basic fibroblast growth factor and its mRNA in advanced ovarian cancers.

To investigate whether growth, invasion and metastasis of ovarian cancer cells is associated with neovascularization, the expression of basic fibroblast growth factor (FGF) and its mRNA in ovarian cancers and normal ovaries as controls were determined by ELISA and reverse transcription-polymerase chain reaction-Southern blot, respectively. The relationships between the expression and the histological grading, clinical backgrounds or clinical staging in ovarian cancers were analyzed. The levels of basic FGF and its mRNA were significantly higher in advanced primary ovarian cancers, regardless of histological types and some clinical backgrounds. Therefore, this status might contribute to the acceleration of growth, invasion, and metastasis with neovascularization in advanced ovarian cancers.