| Literature DB >> 9377084 |
B Bonnet1, D Soullez, E Davioud-Charvet, V Landry, D Horvath, C Sergheraert.
Abstract
Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cruzi trypanothione reductase. IC50 values were assessed between 0.3 and 3 microM. Compound 32 (Ki = 0.4 microM) is the most potent TR inhibitor described so far.Entities:
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Year: 1997 PMID： 9377084 DOI： 10.1016/s0968-0896(97)00070-9
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641