Chiral resolution of flobufen by high performance liquid chromatography and capillary electrophoresis.

The enantiomeric separation of an anti-inflammatory drug flobufen was performed on various chiral columns in liquid chromatography and by reversed phase chromatography and by capillary electrophoresis with beta-cyclodextrin as a chiral selector in the mobile phase and background electrolyte, respectively. The elution order of individual enantiomers is discussed with respect to the absolute chirality of (+/-)-flobufen determined by X-ray crystallography.